• Express System: E.coli
  • Product Tag: C-His-Avi
  • Activity: Immobilized Anti-HLA-A*02:01&B2M&P53 R175H Antibody, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for APC-Labeled Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer, His Tag with the EC50 of 21.1ng/ml determined by ELISA.
  • Amino Acid Range: Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and HMTEVVRHC peptide
Catalog #MHC-HE011TC
Price
Regular price $1,05000
Regular price Sale price $1,05000
/
Size
Avantor VWR Fisher Scientific

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APC-Labeled Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein (MHC-HE011TC) Summary

Product Description

 Recombinant APC-Labeled Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein is expressed from E.coli with His tag and Avi tag at the C-terminus. APC-Labeled Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer is assembled by biotinylated monomer and APC-Labeled streptavidin.It contains Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and HMTEVVRHC peptide.

Product Background

 p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Specifications

Protein
 HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC)
Synonyms
 MHC; HLA-A; P53; TP53; Antigen NY-CO-13; BCC7; FLJ92943; LFS1; TRP53;Antigen NY-CO13
MHC Form
 Tetramer
Allele
 HLA-A*02:01
Accession
Species
 Human
Biotinylated
 no
Amino Acid Range
 Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and HMTEVVRHC peptide
Activity
 Immobilized Anti-HLA-A*02:01&B2M&P53 R175H Antibody, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for APC-Labeled Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer, His Tag with the EC50 of 21.1ng/ml determined by ELISA.
Product Tag
 C-His-Avi
Fluorophore
 APC-Labeled
Expression System
 E.coli

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in 20mM Tris, 200mM NaCl, 0.2% BSA (pH 8.0).
Stability And Storage
 Valid for 6 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Immobilized Anti-HLA-A*02:01&B2M&P53 R175H Antibody, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for APC-Labeled Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer, His Tag with the EC50 of 21.1ng/ml determined by ELISA. Immobilized Anti-HLA-A*02:01&B2M&P53 R175H Antibody, hFc Tag at 2ug/ml (100ul/well) on the plate. Dose response curve for APC-Labeled Human HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer, His Tag with the EC50 of 21.1ng/ml determined by ELISA.
Other Available Proteins:
Finding available proteins...