Product Description |
Recombinant Biotinlylated Human HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Gly21-Thr301(HLA-B*15:01), Ile21-Met119(B2M) and NQKLIANQF peptide. |
Product Background |
HLA-B*15:01 is strongly associated with asymptomatic infection with SARS-CoV-2 and is likely to be involved in the mechanism underlying early viral clearance. T cells from pre-pandemic individuals carrying HLA-B*15:01 were reactive to the immunodominant SARS-CoV-2 S-derived peptide NQKLIANQF, and 100% of the reactive cells displayed memory phenotype. |
Product Category |
Recombinant Protein |
Target |
HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer |
Synonyms |
MHC; SARS-CoV-2 epitope; |
MHC Form |
Monomer |
Allele |
HLA-B*15:01 |
Accession |
AAA53258.1(HLA-B*15:01)&P61769(B2M)&NQKLIANQF |
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Gly21-Thr301(HLA-B*15:01), Ile21-Met119(B2M) and NQKLIANQF peptide |
Molecular Weight |
The protein has a predicted MW of 50.50 kDa. Due to glycosylation, the protein migrates to 52-68 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His-Avi |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Biotinlylated Human HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Biotinlylated Human HLA-B*15:01&B2M&SARS-CoV-2 epitope (NQKLIANQF) Monomer is greater than 95% as determined by SEC-HPLC. |
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