Name: Biotinylated Cynomolgus CDH17/Cadherin 17 Protein (CDH-CM427B)
Brand: KactusBio
SKU: CDH-CM427B-100UG
Price: 578.0 USD
Availability: InStock

Biotinylated Cynomolgus CDH17/Cadherin 17 Protein (CDH-CM427B)

Immobilized Biotinylated Cynomolgus CDH17, His Avi Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 2.3ng/ml determined by ELISA.

Biotinylated Cynomolgus CDH17 on Bis-Tris PAGE under reduced condition. The purity is greater than 90%.

The purity of Biotinylated Cynomolgus CDH17 is greater than 85% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 90% as determined by Bis-Tris PAGE;> 85% as determined by HPLC
Activity: Immobilized Biotinylated Cynomolgus CDH17, His Avi Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 2.3ng/ml determined by ELISA.
Amino Acid Range: Gln23-Thr784
Other Available Proteins:

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Catalog #CDH-CM427B

Size

100UG

500UG

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Biotinylated Cynomolgus CDH17/Cadherin 17 Protein (CDH-CM427B) Summary

Product Description	Recombinant Biotinylated Cynomolgus CDH17/Cadherin 17 Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Gln23-Thr784.
Product Background	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Product Category	Recombinant Protein / Antibody discovery / ADC targets

Biotinylated Cynomolgus CDH17/Cadherin 17 Protein (CDH-CM427B) Specifications/Details

Protein	CDH17/Cadherin 17
Synonyms	Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16;
Accession	XP_005563762.2
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Gln23-Thr784
Molecular Weight	The protein has a predicted MW of 87.39 kDa. Due to glycosylation, the protein migrates to 110-130 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Biotinylated Cynomolgus CDH17, His Avi Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 2.3ng/ml determined by ELISA.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 90% as determined by Bis-Tris PAGE;> 85% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Immobilized Biotinylated Cynomolgus CDH17, His Avi Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 2.3ng/ml determined by ELISA.
	Biotinylated Cynomolgus CDH17 on Bis-Tris PAGE under reduced condition. The purity is greater than 90%.
	The purity of Biotinylated Cynomolgus CDH17 is greater than 85% as determined by SEC-HPLC.