Biotinylated Cynomolgus/Rhesus macaque FcRn Protein (FRN-CM401B)
  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: The affinity constant of 0.48 uM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Ala24-Ser297(FCGRT) & Ile21-Met119(B2M)
Catalog #FRN-CM401B
Regular price $525.00
/
Size

Order now, ships by:

Product Description
Recombinant Biotinylated Cynomolgus/Rhesus macaque FcRn Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Ala24-Ser297(FCGRT) and Ile21-Met119(B2M).
Product Background
The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells.FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51, and p14 , and forms an MHC class I-like heterodimer.
Product Category
Recombinant Protein
Target
FcRn
Synonyms
FcRn alpha chain; FCGRT; FCRN; FCGRT&B2M
Accession
Species
Cynomolgus/Rhesus macaque
Biotinylated
yes
Amino Acid Range
Ala24-Ser297(FCGRT) & Ile21-Met119(B2M)
Molecular Weight
The protein has a predicted MW of 46.5 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Bis-Tris PAGE result.
Activity
The affinity constant of 0.48 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag
C-His-Avi
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Biotinylated Cynomolgus/Rhesus macaque FcRn, His Tag captured on CM5 Chip via Anti-His Antibody can bind Rituximab, hFc Tag with an affinity constant of 0.48 uM as determined in SPR assay (Biacore T200).
Biotinylated Cynomolgus/Rhesus macaque FcRn on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Biotinylated Cynomolgus/Rhesus macaque FcRn is greater than 95% as determined by SEC-HPLC.

Have more questions?

Check out our Frequently Asked Questions page for more details about product specifications, ordering, and shipments.

Contact Us

support@kactusbio.us

Recently viewed