Name: Biotinylated Cynomolgus/Rhesus macaque FcRn Protein (FRN-CM401B)
Brand: KactusBio
SKU: FRN-CM401B-100UG
Price: 577.5 USD
Availability: InStock

Biotinylated Cynomolgus/Rhesus macaque FcRn Protein (FRN-CM401B)

Biotinylated Cynomolgus/Rhesus macaque FcRn, His Tag captured on CM5 Chip via Anti-His Antibody can bind Rituximab, hFc Tag with an affinity constant of 0.48 uM as determined in SPR assay (Biacore T200).

Biotinylated Cynomolgus/Rhesus macaque FcRn on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Biotinylated Cynomolgus/Rhesus macaque FcRn is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 0.48 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Ala24-Ser297(FCGRT) & Ile21-Met119(B2M)

Catalog #FRN-CM401B

Size

100UG

500UG

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Product Description	Recombinant Biotinylated Cynomolgus/Rhesus macaque FcRn Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Ala24-Ser297(FCGRT) and Ile21-Met119(B2M).
Product Background	The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells.FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51, and p14 , and forms an MHC class I-like heterodimer.
Product Category	Recombinant Protein / Antibody discovery / Fc receptors

Protein	FcRn
Synonyms	FcRn alpha chain; FCGRT; FCRN; FCGRT&B2M
Accession	Q8SPV9&Q8SPW0
Species	Cynomolgus/Rhesus macaque
Biotinylated	yes
Amino Acid Range	Ala24-Ser297(FCGRT) & Ile21-Met119(B2M)
Molecular Weight	The protein has a predicted MW of 46.5 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Bis-Tris PAGE result.
Activity	The affinity constant of 0.48 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Biotinylated Cynomolgus/Rhesus macaque FcRn, His Tag captured on CM5 Chip via Anti-His Antibody can bind Rituximab, hFc Tag with an affinity constant of 0.48 uM as determined in SPR assay (Biacore T200).
	Biotinylated Cynomolgus/Rhesus macaque FcRn on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Biotinylated Cynomolgus/Rhesus macaque FcRn is greater than 95% as determined by SEC-HPLC.