Name: Biotinylated Cynomolgus GDF15 Protein (Primary Amine Labeling) (GDF-CM215B)
Brand: KactusBio
SKU: GDF-CM215B-100UG
Price: 742.5 USD
Availability: InStock

ELISA assay curve showing binding response of biotinylated Cynomolgus GDF15 (hFc tag) to Cynomolgus GFRAL (His tag), with absorbance measured at OD450.

Biotinylated Cynomolgus GDF15 Protein (Primary Amine Labeling) (GDF-CM215B)

Immobilized Cynomolgus GFRAL, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Cynomolgus GDF15, hFc Tag with the EC50 of 11.4ng/ml determined by ELISA.

Biotinylated Cynomolgus GDF15 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Biotinylated Cynomolgus GDF15 is greater than 90% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: N-hFc
Purity: > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Activity: Immobilized Cynomolgus GFRAL, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Cynomolgus GDF15, hFc Tag with the EC50 of 11.4ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Ala197-Val308

Catalog #GDF-CM215B

Size

100UG

500UG

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Product Description	Recombinant Biotinylated Cynomolgus GDF15 Protein (Primary Amine Labeling) is expressed from HEK293 with hFc tag at the N-Terminus.It contains Ala197-Val308.
Product Background	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Protein	GDF15
Synonyms	GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta; Placental TGF-β; PTGF-β; PTGFBPTGF-β
Accession	G7PWZ3
Species	Cynomolgus
Biotinylated	yes
Amino Acid Range	Ala197-Val308
Molecular Weight	The protein has a predicted MW of 37.9 kDa. Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus GFRAL, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Cynomolgus GDF15, hFc Tag with the EC50 of 11.4ng/ml determined by ELISA. See testing image for detail.
Product Tag	N-hFc
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 24 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Cynomolgus GFRAL, His Tag at 1ug/ml (100ul/Well) on the plate. Dose response curve for Biotinylated Cynomolgus GDF15, hFc Tag with the EC50 of 11.4ng/ml determined by ELISA.
	Biotinylated Cynomolgus GDF15 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Biotinylated Cynomolgus GDF15 is greater than 90% as determined by SEC-HPLC.

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