Name: Biotinylated Cynomolgus IFN alpha/beta R1 Protein (IFN-CM4R1B)
Brand: KactusBio
SKU: IFN-CM4R1B-100UG
Price: 577.5 USD
Availability: InStock

Biotinylated Cynomolgus IFN alpha/beta R1 Protein (IFN-CM4R1B)

Biotinylated Cynomolgus IFN alpha/beta R1, His-Avi Tag captured on CM5 Chip via Streptavidin can bind Human IFN alpha 1, hFc Tag with an affinity constant of 1.16 nM as determined in SPR assay (Biacore T200).

Biotinylated Cynomolgus IFN alpha/beta R1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Loaded Biotinylated Cynomolgus IFN alpha / beta R1, His-Avi Tag on Streptavidin-Biosensor, can bind Human IFN alpha 1, hFc Tag with an affinity constant of 2.71 nM as determined in BLI assay (Gator).

The purity of Biotinylated Cynomolgus IFN alpha/beta R1 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 1.16 nM as determined in SPR assay (Biacore T200).
Amino Acid Range: Ala25-Lys437

Catalog #IFN-CM4R1B

Size

100UG

500UG

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Biotinylated Cynomolgus IFN alpha/beta R1 Protein (IFN-CM4R1B) Summary

Product Description	Recombinant Biotinylated Cynomolgus IFN alpha/beta R1 Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Ala25-Lys437.
Product Background	IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions.Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Biotinylated Cynomolgus IFN alpha/beta R1 Protein (IFN-CM4R1B) Specifications/Details

Protein	IFN alpha/beta R1
Synonyms	AVP; IFN-alpha/beta R1; IFN-alpha-REC; IFNAR; IFNAR1; IFN-aR1; IFNBR; IFNbR1; IFN-R-1; CRF2-1; IFRC ; IFN-alpha/β R1
Accession	A0A7N9D7J0
Species	Cynomolgus
Biotinylated	yes
Amino Acid Range	Ala25-Lys437
Molecular Weight	The protein has a predicted MW of 50.35 kDa. Due to glycosylation, the protein migrates to 75-105 kDa based on Bis-Tris PAGE result.
Activity	The affinity constant of 1.16 nM as determined in SPR assay (Biacore T200).
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Biotinylated Cynomolgus IFN alpha/beta R1, His-Avi Tag captured on CM5 Chip via Streptavidin can bind Human IFN alpha 1, hFc Tag with an affinity constant of 1.16 nM as determined in SPR assay (Biacore T200).
	Biotinylated Cynomolgus IFN alpha/beta R1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	Loaded Biotinylated Cynomolgus IFN alpha / beta R1, His-Avi Tag on Streptavidin-Biosensor, can bind Human IFN alpha 1, hFc Tag with an affinity constant of 2.71 nM as determined in BLI assay (Gator).
	The purity of Biotinylated Cynomolgus IFN alpha/beta R1 is greater than 95% as determined by SEC-HPLC.