Biotinylated Cynomolgus IFN alpha/beta R1 Protein (IFN-CM4R1B)

  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Biotinylated: yes
  • Activity: The affinity constant of 1.26 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Exact Sequence: Ala25-Lys437

Catalog: IFN-CM4R1B

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Product Description Recombinant Biotinylated Cynomolgus IFN alpha/beta R1 Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Ala25-Lys437.

Product Background

IFN-alpha / beta R1, also known as IFNAR1, belongs to the class II cytokine receptor family of proteins. Class II cytokine receptors form heterodimeric receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions.Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves.

Product Category

Recombinant Protein

Target

IFN alpha/beta R1

Gene/Protein ID

A0A7N9D7J0

Species

Cynomolgus

Exact Sequence

Ala25-Lys437
Molecular Weight The protein has a predicted MW of 50.35 kDa. Due to glycosylation, the protein migrates to 75-105 kDa based on Tris-Bis PAGE result.

Activity

The affinity constant of 1.26 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

C-His-Avi

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Biotinylated- Cynomolgus IFN alpha/beta R1, His-Avi Tag captured on CM5 Chip via Anti-His Antibody can bind Human IFN alpha 1, hFc Tag with an affinity constant of 1.26 nM as determined in SPR assay (Biacore T200).
The purity of Biotinylated Cynomolgus IFN alpha/beta R1 is greater than 95% as determined by SEC-HPLC.
Biotinylated Cynomolgus IFN alpha/beta R1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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