Biotinylated Cynomolgus IFN alpha/beta R2 Protein (IFN-CM4R2B)

  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Biotinylated: yes
  • Activity: The affinity constant of 0.13 uM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Exact Sequence: Ile27-Lys243

Catalog: IFN-CM4R2B

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Product Description Recombinant Biotinylated Cynomolgus IFN alpha/beta R2 Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Ile27-Lys243.

Product Background

Although interferon (IFN)-α is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding IFN-stimulated genes (ISGs), little is known about IFN-α-regulated miRNAs in DCs. Since several miRNAs are involved in regulating DC functions, it is important to investigate whether IFN-α's effects on DCs are mediated through miRNAs as well.

Product Category

Recombinant Protein

Target

IFN alpha/beta R2

Gene/Protein ID

EHH53981.1

Species

Cynomolgus

Exact Sequence

Ile27-Lys243
Molecular Weight The protein has a predicted MW of 27.75 kDa. Due to glycosylation, the protein migrates to 45-60 kDa based on Tris-Bis PAGE result.

Activity

The affinity constant of 0.13 uM as determined in SPR assay (Biacore T200). See testing image for detail.

Product Tag

C-His-Avi

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Biotinylated Cynomolgus IFN alpha/beta R2, His-Avi Tag captured on CM5 Chip via Anti-His Antibody can bind Human IFN alpha 1, hFc Tag with an affinity constant of 0.13 uM as determined in SPR assay (Biacore T200).
The purity of Biotinylated Cynomolgus IFN alpha/beta R2 is greater than 95% as determined by SEC-HPLC.
Biotinylated Cynomolgus IFN alpha/beta R2 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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