Regular price
$660.00
Order by 4pm ET for delivery on:
Biotinylated Cynomolgus Latent GDF-8 Protein (pro&latent) (GDF-CM408B) Summary
Product Description |
Recombinant Biotinylated Cynomolgus Latent GDF-8 Protein (pro&latent) is expressed from HEK293 with His tag and Avi tag at the N-terminus.It contains Gly19-Ser375. |
Product Background |
Growth/differentiation factor 8 (GDF8), or myostatin, negatively regulates muscle mass. GDF8 is held in a latent state through interactions with its N-terminal prodomain. GDF8, like numerous TGF-β family members, is a disulfidelinked dimer that is synthesized as a precursor protein which requires cleavage by a furin-like protease to yield an N-terminal prodomain and a C-terminal mature, signaling domain. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery/Others |
Biotinylated Cynomolgus Latent GDF-8 Protein (pro&latent) (GDF-CM408B) Specifications/Details
Protein |
GDF-8 |
Synonyms |
Myostatin; GDF8; Latent GDF8; Mstn |
Accession |
|
Species |
Cynomolgus |
Biotinylated |
yes |
Amino Acid Range |
Gly19-Ser375 |
Molecular Weight |
The protein has a predicted MW of 43.45 kDa. Due to glycosylation, the protein migrates to 13-15 kDa, 38-41 kDa and 48-52 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Biotinylated Cynomolgus Latent GDF-8, His Avi Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Apitegromab, hFc Tag with the EC50 of 2.8ng/ml determined by ELISA. |
Product Tag |
N-His-Avi |
Fluorophore |
Biotin-labeled |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Immobilized Biotinylated Cynomolgus Latent GDF-8, His Avi Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Apitegromab, hFc Tag with the EC50 of 2.8ng/ml determined by ELISA. |
|
|
Biotinylated Cynomolgus Latent GDF-8 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Biotinylated Cynomolgus Latent GDF-8 is greater than 90% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
Related Products
Have more questions?
Check out our Frequently Asked Questions page for more details about product specifications, ordering, and shipments.
Contact Us
Recommended Products
Loading...
Recently viewed
