Name: Biotinylated Cynomolgus SOST/Sclerostin Protein (SOT-CM401B)
Brand: KactusBio
SKU: SOT-CM401B-100UG
Availability: InStock

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Activity: Immobilized Biotinylated Cynomolgus SOST, His Avi Tag at 1ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Human LRP-6, mFc Tag with the EC50 of 37.6ng/ml determined by ELISA.
Amino Acid Range: Gln69-Tyr258

Catalog #SOT-CM401B

Size

100UG

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Biotinylated Cynomolgus SOST/Sclerostin Protein (SOT-CM401B) Summary

Product Description	Recombinant Biotinylated Cynomolgus SOST/Sclerostin Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Gln69-Tyr258.
Product Background	SOST, also known as sclerostin, is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. SOST is negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery \| Others

Biotinylated Cynomolgus SOST/Sclerostin Protein (SOT-CM401B) Specifications/Details

Protein	SOST/Sclerostin
Synonyms	sclerostin; SOST; VBCHsclerosteosis; CDD; DAND6; SOST1; VBCH
Accession	XP_005584428.2
Species	Cynomolgus
Biotinylated	yes
Amino Acid Range	Gln69-Tyr258
Molecular Weight	The protein has a predicted MW of 24.39 kDa. Due to glycosylation, the protein migrates to 32-38 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Biotinylated Cynomolgus SOST, His Avi Tag at 1ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Human LRP-6, mFc Tag with the EC50 of 37.6ng/ml determined by ELISA.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS, 200mM L-arginine (pH 7.4).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Biotinylated Cynomolgus SOST, His Avi Tag at 1ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Human LRP-6, mFc Tag with the EC50 of 37.6ng/ml determined by ELISA.
	Immobilized Biotinylated Cynomolgus SOST, His Avi Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-SOST Antibody, hFc Tag with the EC50 of 15.0ng/ml determined by ELISA.
	Biotinylated Cynomolgus SOST on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Biotinylated Cynomolgus SOST is greater than 90% as determined by SEC-HPLC.