Biotinylated Human CCR2b Protein-VLP (CCR-HM02BB)
  • Express System: HEK293
  • Purity: > 95% as determined by HPLC
  • Activity: Immobilized Biotinylated Human CCR2b VLP at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CCR2 Antibody, hFc Tag with the EC50 of 0.21ug/ml determined by ELISA (QC Test). The affinity constant of 2.19 nM as determined in SPR assay (Biacore T200). See testing image for detail.
  • Amino Acid Range: Met1-Leu360
Catalog #CCR-HM02BB
Regular price $2,165.90
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Product Description

Recombinant Biotinylated Human CCR2b Protein-VLP is expressed from HEK293.It contains Met1-Leu360 (It may have cross reaction with anti-His antibody).

Product Background

The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammatory diseases. The actin-binding protein filamin A (FLNa) as a protein that associates with the carboxyl-terminal tail of CCR2B. FLNa emerges as an important protein for controlling the internalization and spatial localization of the CCR2B receptor in different dynamic membrane structures.

Product Category

Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / VLP

Protein

CCR2b

Synonyms

C-C CKR-2; CCR-2; CCR2; MCP-1-R; CMKBR2; CCR2

Accession

Species

Human

Biotinylated

yes

Amino Acid Range

Met1-Leu360

Molecular Weight

The target protein has a predicted MW of 42.9kDa.

Activity

Immobilized Biotinylated Human CCR2b VLP at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CCR2 Antibody, hFc Tag with the EC50 of 0.21ug/ml determined by ELISA (QC Test). The affinity constant of 2.19 nM as determined in SPR assay (Biacore T200). See testing image for detail.

Expression System

HEK293

Purity

> 95% as determined by HPLC

Endotoxin

Less than 1 EU per ug by the LAL method.
Form
Liquid
Shipping
Shipped with dry ice.
Formulation
Supplied as 0.22um filtered solution in PBS, 300mM L-Arginine (pH 7.4).
Stability And Storage
Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Biotinylated CCR2B VLP captured on CM5 Chip via streptavidin can bind Anti-CCR2 Antibody, hFc with an affinity constant of 2.19 nM as determined in SPR assay (Biacore T200). Biotinylated CCR2B VLP captured on CM5 Chip via streptavidin can bind Anti-CCR2 Antibody, hFc with an affinity constant of 2.19 nM as determined in SPR assay (Biacore T200).
Immobilized Biotinylated Human CCR2b VLP at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CCR2 Antibody, hFc Tag with the EC50 of 0.21ug/ml determined by ELISA (QC Test). Immobilized Biotinylated Human CCR2b VLP at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CCR2 Antibody, hFc Tag with the EC50 of 0.21ug/ml determined by ELISA (QC Test).
The purity of Biotinylated Human CCR2b VLP is greater than 95% as determined by SEC-HPLC. The purity of Biotinylated Human CCR2b VLP is greater than 95% as determined by SEC-HPLC.

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