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Biotinylated Human CCR4 Nanodisc (CCR-HM14NB) Summary
Product Description |
Recombinant Biotinylated Human CCR4 Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Leu360. |
Product Background |
CC chemokine receptor 4 (CCR4) is a chemokine receptor mainly expressed by T cells. CCR4 is important in the pathogenesis of many diseases, such as diabetes, multiple sclerosis, asthma, dermatitis, and cancer. This review briefly characterizes CCR4 and its ligands (CCL17, CCL22, and CCL2), and their contributions to immunological and neoplastic diseases. |
Product Category |
Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / Nanodisc |
Biotinylated Human CCR4 Nanodisc (CCR-HM14NB) Specifications/Details
Protein |
CCR4 |
Synonyms |
C-C CKR-4; CC-CKR-4; CCR-4; CCR4; K5-5; CD194; CMKBR4; CKR-4 |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Met1-Leu360 |
Molecular Weight |
The protein has a predicted MW of 54.3 kDa. |
Activity |
Immobilized Biotinylated Human CCR4 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CCR4 Antibody, hFc Tag with the EC50 of 7.5ng/ml determined by ELISA. The affinity constant of 0.64 nM as determined in SPR assay (Biacore T200). |
Product Tag |
C-His |
Fluorophore |
Biotin-labeled |
Expression System |
HEK293 |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS, 200mM L-arginine (pH 7.4). |
Stability And Storage |
Valid for 6 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Biotinylated Human CCR4 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-CCR4 Antibody, hFc Tag with an affinity constant of 0.64 nM as determined in SPR assay (Biacore T200). |
|
|
Immobilized Biotinylated Human CCR4 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CCR4 Antibody, hFc Tag with the EC50 of 7.5ng/ml determined by ELISA. |
Other Available Proteins:
Finding available proteins...
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