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Biotinylated Human CCR7 Nanodisc (CCR-HM17NB) Summary
Product Description |
Recombinant Biotinylated Human CCR7 Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Pro378. |
Product Background |
CC-chemokine receptor 7 (CCR7), collaborated with its ligands CCL19 and CCL21, controls extensive migratory events in the immune system. CCR7-bearing dendritic cells can swarm into T-cell zones in lymph nodes, initiating the antigen presentation and T-cell response. Abnormal expression of CCR7 in dendritic cells will cause a series of inflammatory diseases due to the chaotic dendritic cell trafficking. |
Product Category |
Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / Nanodisc |
Biotinylated Human CCR7 Nanodisc (CCR-HM17NB) Specifications/Details
Protein |
CCR7 |
Synonyms |
CCR7; C-C CKR-7; CC-CKR-7; CCR-7; BLR2; CDw197; EBI1; CD197; CMKBR7; EBI1; EVI1 |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Met1-Pro378 |
Molecular Weight |
The protein has a predicted MW of 55.80 kDa. |
Activity |
Immobilized Biotinylated Human CCR7 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CCR7 Antibody, hFc Tag with the EC50 of 23.7ng/ml determined by ELISA (QC Test). The affinity constant of 2.99 nM as determined in SPR assay (Biacore T200). |
Product Tag |
C-His |
Fluorophore |
Biotin-labeled |
Expression System |
HEK293 |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS, 200mM L-arginine (pH 7.4). |
Stability And Storage |
Valid for 6 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Biotinylated Human CCR7 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-CCR7 Antibody, hFc Tag with an affinity constant of 2.99 nM as determined in SPR assay (Biacore T200). |
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Immobilized Biotinylated Human CCR7 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CCR7 Antibody, hFc Tag with the EC50 of 23.7ng/ml determined by ELISA (QC Test). |
Other Available Proteins:
Finding available proteins...
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