Name: Biotinylated Human CDH17/Cadherin 17 Domain 5-7 Protein (CDH-HM4D4B)
Brand: KactusBio
SKU: CDH-HM4D4B-100UG
Price: 577.5 USD
Availability: InStock

Biotinylated Human CDH17/Cadherin 17 Domain 5-7 Protein (CDH-HM4D4B)

Immobilized Biotinylated Human CDH17 Domain 5-7, His Avi Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CDH17 Domain 5-7 Antibody, hFc Tag with the EC50 of 10.7ng/ml determined by ELISA.

Biotinylated Human CDH17 Domain 5-7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Loaded Anti-CDH17 Domain 5-7 Antibody, hFc Tag on ProA-Biosensor can bind Biotinylated Human CDH17 Domain 5-7, His Avi Tag with an affinity constant of 2.89 nM as determined in BLI assay (Gator® Prime).

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE
Activity: Immobilized Biotinylated Human CDH17 Domain 5-7, His Avi Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CDH17 Domain 5-7 Antibody, hFc Tag with the EC50 of 10.7ng/ml determined by ELISA.
Amino Acid Range: Glu450-Gly777

Catalog #CDH-HM4D4B

Size

100UG

500UG

Order by 4pm ET for delivery on:

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Biotinylated Human CDH17/Cadherin 17 Domain 5-7 Protein (CDH-HM4D4B) Summary

Product Description	Recombinant Biotinylated Human CDH17/Cadherin 17 Domain 5-7 Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Glu450-Gly777.
Product Background	Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Product Category	Recombinant Protein / Antibody discovery / ADC targets

Biotinylated Human CDH17/Cadherin 17 Domain 5-7 Protein (CDH-HM4D4B) Specifications/Details

Protein	CDH17/Cadherin 17
Synonyms	Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16; FLJ26931; MGC138218; MGC142024
Accession	Q12864
Species	Human
Biotinylated	yes
Amino Acid Range	Glu450-Gly777
Molecular Weight	The protein has a predicted MW of 38.6 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Biotinylated Human CDH17 Domain 5-7, His Avi Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CDH17 Domain 5-7 Antibody, hFc Tag with the EC50 of 10.7ng/ml determined by ELISA.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE
Endotoxin	Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Immobilized Biotinylated Human CDH17 Domain 5-7, His Avi Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CDH17 Domain 5-7 Antibody, hFc Tag with the EC50 of 10.7ng/ml determined by ELISA.
	Biotinylated Human CDH17 Domain 5-7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	Loaded Anti-CDH17 Domain 5-7 Antibody, hFc Tag on ProA-Biosensor can bind Biotinylated Human CDH17 Domain 5-7, His Avi Tag with an affinity constant of 2.89 nM as determined in BLI assay (Gator® Prime).