Product Description |
Recombinant Biotinylated Human CDH17/Cadherin 17 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Gln23-Met787. |
Product Background |
Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach. |
Product Category |
Recombinant Protein |
Target |
Biotinylated CDH17/Cadherin 17 |
Synonyms |
Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16; |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Gln23-Met787 |
Molecular Weight |
The protein has a predicted MW of 87.88 kDa. Due to glycosylation, the protein migrates to 105-120 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Biotinylated Human CDH17, His Tag at 0.5ug/ml (100ul/Well) on streptavidin (5ug/ml) precoated plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His-Avi |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Immobilized Biotinylated Human CDH17, His Tag at 0.5ug/ml (100ul/Well) on streptavidin (5ug/ml) precoated plate. Dose response curve for Anti-CDH17 Antibody, hFc Tag with the EC50 of 5.0ng/ml determined by ELISA. |
|
|
Biotinylated Human CDH17 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Biotinylated Human CDH17 is greater than 95% as determined by SEC-HPLC. |
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