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Biotinylated Human CEACAM-5/CD66e (499-685) Protein (CAM-HM4D4B) Summary
Product Description |
Recombinant Biotinylated Human CEACAM-5/CD66e (499-685) Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Glu499-Ala685. |
Product Background |
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) was identified as a metastatic driver. CEACAM5 overproduction enriched for an epithelial gene expression pattern and facilitated tumor outgrowth at metastatic sites. Tissues from patients with metastatic breast cancer confirmed elevated levels of CEACAM5 in lung metastases relative to breast tumors, and an inverse correlation between CEACAM5 and the mesenchymal marker vimentin was demonstrated. |
Product Category |
Recombinant Protein / Antibody discovery / CAR-T targets, ADC targets |
Biotinylated Human CEACAM-5/CD66e (499-685) Protein (CAM-HM4D4B) Specifications/Details
Protein |
CEACAM-5/CD66e |
Synonyms |
CEACAM-5; CD66e; CEA; Meconium antigen 100; Carcinoembryonic; CEACD66e; DKFZp781M2392 |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Glu499-Ala685 |
Molecular Weight |
The protein has a predicted MW of 22.94 kDa. Due to glycosylation, the protein migrates to 52-65 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Biotinylated Human CEACAM-5 (499-685), His Avi Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CEACAM-5 Antibody, hFc Tag with the EC50 of 3.6ng/ml determined by ELISA. |
Product Tag |
C-His-Avi |
Fluorophore |
Biotin-labeled |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Biotinylated Human CEACAM-5 (499-685), His Avi Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CEACAM-5 Antibody, hFc Tag with the EC50 of 3.6ng/ml determined by ELISA. |
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Biotinylated Human CEACAM-5 (499-685) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Biotinylated Human CEACAM-5 (499-685) is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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