Name: Biotinylated Human Claudin 4 Protein-Nanodisc (CLD-HM14NB)
Brand: KactusBio
SKU: CLD-HM14NB-100UG
Price: 2165.9 USD
Availability: InStock

Biotinylated Human Claudin 4 Protein-Nanodisc (CLD-HM14NB)

Biotinylated Human Claudin 4 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-Claudin 4 Antibody, hFc Tag with an affinity constant of 6.145 nM as determined in SPR assay (Biacore T200).

Immobilized Biotinylated Human Claudin 4 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 6.6ng/ml determined by ELISA (QC Test).

Express System: HEK293
Product Tag: C-His
Activity: Immobilized Biotinylated Human Claudin 4 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 6.6ng/ml determined by ELISA (QC Test). The affinity constant of 6.145 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Met1-Val209

Catalog #CLD-HM14NB

Size

100UG

100UG X 5

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Product Description	Recombinant Biotinylated Human Claudin 4 Protein-Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Val209.
Product Background	Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.
Product Category	Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / Nanodisc

Protein	Claudin 4
Synonyms	Claudin-4; CLDN4; Claudin4; CPE-R; CPE R; CPETR1; WBSCR8
Accession	O14493
Species	Human
Biotinylated	yes
Amino Acid Range	Met1-Val209
Molecular Weight	The protein has a predicted MW of 35.0 kDa.
Activity	Immobilized Biotinylated Human Claudin 4 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 6.6ng/ml determined by ELISA (QC Test). The affinity constant of 6.145 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Biotinylated Human Claudin 4 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-Claudin 4 Antibody, hFc Tag with an affinity constant of 6.145 nM as determined in SPR assay (Biacore T200).
	Immobilized Biotinylated Human Claudin 4 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 6.6ng/ml determined by ELISA (QC Test).