• Express System: HEK293
  • Product Tag: C-His
  • Activity: Immobilized Biotinylated Human CRTh2 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CRTh2 Antibody, hFc Tag with the EC50 of 56.4ng/ml determined by ELISA.
  • Amino Acid Range: Met1-Ser395
Catalog #CRT-HM1HNB
Price
Regular price $2,16600
Regular price Sale price $2,16600
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Size
Avantor VWR Fisher Scientific

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Biotinylated Human CRTh2 Nanodisc (CRT-HM1HNB) Summary

Product Description

 Recombinant Biotinylated Human CRTh2 Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Ser395.

Product Background

 A seven-transmembrane receptor, CRTH2, which is preferentially expressed in T helper type 2 (Th2) cells, eosinophils, and basophils in humans, serves as the novel receptor for PGD2. In response to PGD2, CRTH2 induces intracellular Ca2+ mobilization and chemotaxis in Th2 cells in a Gαi-dependent manner. In addition, CRTH2, but not DP, mediates PGD2-dependent cell migration of blood eosinophils and basophils. Thus, PGD2 is likely involved in multiple aspects of allergic inflammation through its dual receptor systems, DP and CRTH2.

Biotinylated Human CRTh2 Nanodisc (CRT-HM1HNB) Specifications/Details

Protein
 CRTh2
Synonyms
 PTGDR2; CD294; CRTH2; DL1R; GPR44; DP2; DL1R
Accession
Species
 Human
Biotinylated
 yes
Amino Acid Range
 Met1-Ser395
Molecular Weight
 The protein has a predicted MW of 56.22 kDa.
Activity
 Immobilized Biotinylated Human CRTh2 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CRTh2 Antibody, hFc Tag with the EC50 of 56.4ng/ml determined by ELISA.
Product Tag
 C-His
Fluorophore
 Biotin-labeled
Expression System
 HEK293
Endotoxin
 Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS, 200mM L-arginine (pH 7.4). Notice: Not recommended for flow cytometry in mammalian cells.
Stability And Storage
 Valid for 6 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Immobilized Biotinylated Human CRTh2 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CRTh2 Antibody, hFc Tag with the EC50 of 56.4ng/ml determined by ELISA. Immobilized Biotinylated Human CRTh2 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CRTh2 Antibody, hFc Tag with the EC50 of 56.4ng/ml determined by ELISA.
Other Available Proteins:
Finding available proteins...