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Biotinylated Human CXCR6 Nanodisc (CXC-HM16NB) Summary
Product Description |
Recombinant Biotinylated Human CXCR6 Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Leu342. |
Product Background |
CXCR6 is a receptor for the chemokine CXCL16, which exists as a membrane or soluble form. CXCR6 is a marker for resident memory T (TRM) cells that plays a role in immunosurveillance through their interaction with epithelial cells. The interaction of CXCR6 with CXCL16 expressed at the membrane of certain subpopulations of intratumor dendritic cells (DC) called DC3, ideally positions these CXCR6+ T cells to receive a proliferation signal from IL-15 also presented by DC3. |
Product Category |
Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / Nanodisc |
Biotinylated Human CXCR6 Nanodisc (CXC-HM16NB) Specifications/Details
Protein |
CXCR6 |
Synonyms |
CXC-R6; CXCR-6; CDw186; CD186; BONZO; STRL33; TYMSTR |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Met1-Leu342 |
Molecular Weight |
The protein has a predicted MW of 52.2 kDa. |
Activity |
Immobilized Biotinylated Human CXCR6 Nanodisc, His Tag at 1ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CXCR6 Antibody, hFc Tag with the EC50 of 3.2ng/ml determined by ELISA. The affinity constant of 5.96 pM as determined in SPR assay (Biacore T200). |
Product Tag |
C-His |
Fluorophore |
Biotin-labeled |
Expression System |
HEK293 |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS, 200mM L-arginine (pH 7.4). |
Stability And Storage |
Valid for 6 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Biotinylated Human CXCR6 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-CXCR6 Antibody, hFc Tag with an affinity constant of 5.96 pM as determined in SPR assay (Biacore S200). |
|
|
Immobilized Biotinylated Human CXCR6 Nanodisc, His Tag at 1ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CXCR6 Antibody, hFc Tag with the EC50 of 3.2ng/ml determined by ELISA. |
Other Available Proteins:
Finding available proteins...
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