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Biotinylated Human CXCR7 Nanodisc (CXR-HM17NB) Summary
Product Description |
Recombinant Biotinylated Human CXCR7 Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Lys362. |
Product Background |
Atypical chemokine receptor 3 (ACKR3), previously known as C-X-C chemokine receptor type 7 (CXCR7), has emerged as a key player in several biologic processes, particularly during development. Its CXCL11 and CXCL12 scavenging activity and atypical signaling properties, together with a new array of other nonchemokine ligands, have established ACKR3 as a main regulator of physiologic processes at steady state and during inflammation. |
Product Category |
Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / Nanodisc |
Biotinylated Human CXCR7 Nanodisc (CXR-HM17NB) Specifications/Details
Protein |
CXCR7 |
Synonyms |
CXC-R7; CXCR-7; ACKR3; CMKOR1; GPR159; RDC1; RDC-1 |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Met1-Lys362 |
Molecular Weight |
The protein has a predicted MW of 54.4 kDa. |
Activity |
Immobilized Biotinylated Human CXCR7 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CXCR7 Antibody 1, hFc Tag with the EC50 of 24.2ng/ml determined by ELISA. The affinity constant of 3.22 nM as determined in SPR assay (Biacore T200). |
Product Tag |
C-His |
Fluorophore |
Biotin-labeled |
Expression System |
HEK293 |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS, 200mM L-arginine (pH 7.4). |
Stability And Storage |
Valid for 6 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Biotinylated Human CXCR7 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-CXCR7 Antibody 1, hFc Tag with an affinity constant of 3.22 nM as determined in SPR assay (Biacore T200). |
|
|
Immobilized Biotinylated Human CXCR7 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CXCR7 Antibody 1, hFc Tag with the EC50 of 24.2ng/ml determined by ELISA. |
|
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Immobilized Biotinylated Human CXCR7 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-CXCR7 Antibody 2, hFc Tag with the EC50 of 3.5ng/ml determined by ELISA. |
Other Available Proteins:
Finding available proteins...
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