Product Description |
Recombinant Biotinylated Human GPRC5D Protein-VLP is expressed from HEK293.It contains Met1-Val345. |
Product Background |
Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA. |
Product Category |
Recombinant Protein |
Target |
GPRC5D |
Synonyms |
GPRC5D; MGC129713; MGC129714; orphan G-protein coupled receptor |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Met1-Val345 |
Molecular Weight |
The target protein has a predicted MW of 39.6 kDa. |
Activity |
Immobilized Anti-GPRC5D Antibody, hFc Tag at 2ug/ml (100ul/well) can bind various dilution ratio of Biotinylated Human GPRC5D VLP. The affinity constant of 0.30 nM as determined in SPR assay (Biacore T200). See testing image for detail. |
Express System |
HEK293 |
Purity |
> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ul by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22um filtered solution in PBS, 300mM L-Arginine (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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|
Biotinylated Human GPRC5D VLP captured on SA Chip can bind Anti-GPRC5D antibody, hFc Tag with an affinity constant of 0.30 nM as determined in SPR assay (Biacore T200) (QC Test). |
|
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Immobilized Anti-GPRC5D Antibody, hFc Tag at 2ug/ml (100ul/well) can bind various dilution ratio of Biotinylated Human GPRC5D VLP. |
|
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The purity of Biotinylated Human GPRC5D VLP is greater than 95% as determined by SEC-HPLC. |
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