Biotinylated Human Her4/ErbB4 Protein (HER-HM4B4B)
Catalog: HER-HM4B4B
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| Product Description | Recombinant Biotinylated Human Her4/ErbB4 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Gln26-Pro651. |
Product Background |
Her4, a member of the EGF receptor family, plays a variety of roles in physiological and pathological states. Genetic studies have indicated a link between Her4 and type 2 diabetes and obesity. Her4 may play an important role in glucose homeostasis and lipogenesis. Her4 deficiency-related obesity and adipose tissue inflammation may contribute to the development of MetS. |
Product Category |
Recombinant Protein |
Target |
Her4/ErbB4 |
Gene/Protein ID |
Q15303-1 |
Species |
Human |
Exact Sequence |
Gln26-Pro651 |
| Molecular Weight | The protein has a predicted MW of 72.7 kDa. Due to glycosylation, the protein migrates to 75-110 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Biotinylated Human Her4, His Tag at 2ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 8.8ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His-Avi |
Express System |
HEK293 |
| Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
| Endotoxin | Less than 1EU per ug by the LAL method. |
| Form | Lyophilized |
| Shipping | Shipped at ambient temperature. |
| Formulation | Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
| Stability And Storage | Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
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Immobilized Biotinylated Human Her4, His Tag at 2ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 8.8ng/ml determined by ELISA. |
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The purity of Biotinylated Human Her4 is greater than 95% as determined by SEC-HPLC. |
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Biotinylated Human Her4 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%. |
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