Product Description |
Recombinant Biotinylated Human Her4/ErbB4 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Gln26-Pro651. |
Product Background |
Her4, a member of the EGF receptor family, plays a variety of roles in physiological and pathological states. Genetic studies have indicated a link between Her4 and type 2 diabetes and obesity. Her4 may play an important role in glucose homeostasis and lipogenesis. Her4 deficiency-related obesity and adipose tissue inflammation may contribute to the development of MetS. |
Product Category |
Recombinant Protein |
Target |
Her4/ErbB4 |
Synonyms |
p180erbB4; 4ICD; E4ICD; HER4; ErbB4; MGC138404; ALS19 |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Gln26-Pro651 |
Molecular Weight |
The protein has a predicted MW of 72.7 kDa. Due to glycosylation, the protein migrates to 75-110 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Biotinylated Human Her4, His Tag at 2ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 8.8ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His-Avi |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Immobilized Biotinylated Human Her4, His Tag at 2ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Human NRG1 Beta 1, hFc Tag with the EC50 of 8.8ng/ml determined by ELISA. |
|
|
Biotinylated Human Her4 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Biotinylated Human Her4 is greater than 95% as determined by SEC-HPLC. |
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