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Biotinylated Human HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) Monomer Protein (MHC-HM493B) Summary
Product Description |
Recombinant Biotinylated Human HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Gly25-Thr305 (HLA-A*02:01), Ile21-Met119 (B2M) and ILNNFPHSI peptide. |
Product Background |
ILNNFPHSI is a peptide epitope derived from KKLC1 (also known as Kita-kyushu lung cancer antigen 1, CT83 or CXorf61) that is naturally processed and presented on the cell surface in complex with MHC class I molecules. This peptide, together with binding moieties that specifically recognize the peptide–MHC complex, provides a valuable basis for the development of therapeutic agents capable of selectively targeting KKLC1-expressing cancer cells, and holds particular promise for the treatment of malignancies such as non-small cell lung cancer (adenocarcinoma and squamous subtypes) and esophageal cancer. |
Product Category |
Recombinant Protein / Antibody discovery / MHC / Peptide-MHCs |
HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) Specifications
Protein |
HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) |
Synonyms |
KKLC1; KK-LC-1; CT83; CXorf61 |
MHC Form |
Monomer |
Allele |
HLA-A*02:01 |
Accession |
A0A140T913(HLA-A*02:01)&P61769(B2M)&ILNNFPHSI |
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and ILNNFPHSI peptide |
Molecular Weight |
The protein has a predicted MW of 50.50 kDa. Due to glycosylation, the protein migrates to 52-62 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His-Avi |
Fluorophore |
Biotin-labeled |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS, 100mM L-Arginine (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Biotinylated Human HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Biotinylated Human HLA-A*02:01&B2M&KKLC1 (ILNNFPHSI) Monomer is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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