Biotinylated Human HLA-A*03:01&B2M&gp100 (ALLAVGATK) Monomer Protein (MHC-HM463B)

  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Biotinylated: yes
  • Exact Sequence: Gly25-Thr305(HLA-A*03:01), Ile21-Met119(B2M) and ALLAVGATK peptide

Catalog: MHC-HM463B

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Product Description Recombinant Biotinylated Human HLA-A*03:01&B2M&gp100 (ALLAVGATK) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Gly25-Thr305 (HLA-A*03:01), Ile21-Met119 (B2M) and ALLAVGATK peptide.

Product Background

Immunization against the ALLAVGATK peptide may occur in melanoma patients and that the immunogenicity of this peptide is similar to that of the majority of melanoma differentiation antigens defined to date. Therefore, the use of ALLAVGATK in active immunotherapy for HLA-A3 melanoma patients, for whom no other immunogenic peptide has been so far described, remains a distinct possibility, providing that patients treated in vivo with this peptide develop a better in vitro response than already demonstrated for HLA-A2 epitopes generated from this same antigenic protein.

Product Category

Recombinant Protein

Target

HLA-A*03:01&B2M&gp100 (ALLAVGATK) Monomer
MHC Form Monomer
Allele HLA-A*03:01

Gene/Protein ID

NP_002107.3(HLA-A*03:01)&P61769(B2M)&ALLAVGATK

Species

Human

Exact Sequence

Gly25-Thr305(HLA-A*03:01), Ile21-Met119(B2M) and ALLAVGATK peptide
Molecular Weight The protein has a predicted MW of 50.15 kDa. Due to glycosylation, the protein migrates to 51-60 kDa based on Tris-Bis PAGE result.

Product Tag

C-His-Avi

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The purity of Biotinylated Human HLA-A*03:01&B2M&gp100 (ALLAVGATK) Monomer is greater than 95% as determined by SEC-HPLC.
Biotinylated Human HLA-A*03:01&B2M&gp100 (ALLAVGATK) Monomer on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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