Biotinylated Human HLA-A*03:01&B2M&KRAS G12V (VVGAVGVGK) Monomer Protein (MHC-HM456B)

  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Biotinylated: yes
  • Exact Sequence: Gly25-Thr305(HLA-A*03:01), Ile21-Met119(B2M) and VVGAVGVGK peptide

Catalog: MHC-HM456B

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Product Description Recombinant Biotinylated Human HLA-A*03:01&B2M&KRAS G12V (VVGAVGVGK) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-TerminusIt contains Gly25-Thr305 (HLA-A*03:01), Ile21-Met119 (B2M) and VVGAVGVGK peptide.

Product Background

Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

Product Category

Recombinant Protein

Target

HLA-A*03:01&B2M&KRAS G12V (VVGAVGVGK) Monomer
MHC Form Monomer
Allele HLA-A*03:01

Gene/Protein ID

NP_002107.3(HLA-A*03:01)&P61769(B2M)&VVGAVGVGK

Species

Human

Exact Sequence

Gly25-Thr305(HLA-A*03:01), Ile21-Met119(B2M) and VVGAVGVGK peptide
Molecular Weight The protein has a predicted MW of 50.09 kDa. Due to glycosylation, the protein migrates to 51-60 kDa based on Tris-Bis PAGE result.

Product Tag

C-His-Avi

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Liquid
Shipping Shipped with dry ice.
Formulation Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
The purity of Biotinylated Human HLA-A*03:01&B2M&KRAS G12V (VVGAVGVGK) Monomer is greater than 95% as determined by SEC-HPLC.
Biotinylated Human HLA-A*03:01&B2M&KRAS G12V (VVGAVGVGK) Monomer on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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