• Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Cys25-Ala366(HLA-C*08:01), Ile21-Met119(B2M) and GADGVGKSAL peptide
Catalog #MHC-HM492B
Price
Regular price $341.00
Regular price Sale price $341.00
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Size
Avantor VWR Fisher Scientific

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Biotinylated Human HLA-C*08:01&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein (MHC-HM492B) Summary

Product Description

 Recombinant Biotinylated Human HLA-C*08:01&B2M&KRAS G12D (GADGVGKSAL) Monomer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Cys25-Ala366(HLA-C*08:01), Ile21-Met119(B2M) and GADGVGKSAL peptide.

Product Background

 Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) is the most commonly mutated oncogene in human cancer. The developments of many cancers depend on sustained expression and signaling of KRAS, which makes KRAS a high-priority therapeutic target. The virtual screening approach to discover novel KRAS inhibitors and synthetic lethality interactors of KRAS are discussed in detail.

Product Category

 Recombinant Protein / Antibody discovery / MHC / Peptide-MHCs

HLA-C*08:01&B2M&KRAS G12D (GADGVGKSAL) Specifications

Protein
 HLA-C*08:01&B2M&KRAS G12D (GADGVGKSAL)
Synonyms
 MHC; KRAS; K-Ras 2; KRAS2; C-K-RAS; CFC2; K-RAS2A; K-RAS2B; K-RAS4A; K-RAS4B; KRAS1; KRAS2; NS; NS3; RASK2; GTPase Kras; KI-RAS; RALD

MHC Form

 Monomer

Allele

 HLA-C*08:01
Accession
Species
 Human
Biotinylated
 yes
Amino Acid Range
 Cys25-Ala366(HLA-C*08:01), Ile21-Met119(B2M) and GADGVGKSAL peptide
Molecular Weight
 The protein has a predicted MW of 50.60 kDa. Due to glycosylation, the protein migrates to 52-62 kDa based on Bis-Tris PAGE result.
Product Tag
 C-His-Avi

Fluorophore

 Biotin-labeled
Expression System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Biotinylated Human HLA-C*08:01&B2M&KRAS G12D (GADGVGKSAL) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Biotinylated Human HLA-C*08:01&B2M&KRAS G12D (GADGVGKSAL) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Biotinylated Human HLA-C*08:01&B2M&KRAS G12D (GADGVGKSAL) Monomer is greater than 95% as determined by SEC-HPLC. The purity of Biotinylated Human HLA-C*08:01&B2M&KRAS G12D (GADGVGKSAL) Monomer is greater than 95% as determined by SEC-HPLC.
Other Available Proteins:
Finding available proteins...
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