Biotinylated Human IL-17R alpha/CD217 Protein (IL1-HM5RAB)

  • Express System: HEK293
  • Product Tag: C-hFc-Avi
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Biotinylated: yes
  • Activity: Immobilized Human IL-17A&F, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-17R alpha, hFc Tag with the EC50 of 0.94ug/ml determined by ELISA (QC Test). See testing image for detail.
  • Exact Sequence: Leu33-Trp320

Catalog: IL1-HM5RAB

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Product Description Recombinant Biotinylated Human IL-17R alpha/CD217 Protein is expressed from HEK293 with hFc tag and Avi tag at the C-Terminus.It contains Leu33-Trp320.

Product Background

Interleukin 17 (also known as CTLA‑8) is a T cell‑expressed pleotropic cytokine. IL‑17 binds to IL‑17 receptor (IL‑17 R) which shares no homology with any known family of receptors. While the expression of IL‑17 is restricted to activated T cells, the IL‑17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The human IL‑17 R gene was localized to chromosome 22.

Product Category

Recombinant Protein

Target

IL-17R alpha/CD217
Synonyms CD217; CDw217; IL-17RA; IL17R; CANDF5; IL-7R; IL-7R-alpha; ILRA
Accession

Species

Human

Exact Sequence

Leu33-Trp320
Molecular Weight The protein has a predicted MW of 61.8 kDa. Due to glycosylation, the protein migrates to 78-100 kDa based on Tris-Bis PAGE result.

Activity

Immobilized Human IL-17A&F, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-17R alpha, hFc Tag with the EC50 of 0.94ug/ml determined by ELISA (QC Test). See testing image for detail.

Product Tag

C-hFc-Avi

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Human IL-17A&F, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-17R alpha, hFc Tag with the EC50 of 0.94ug/ml determined by ELISA (QC Test).
Immobilized Human IL-17F, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-17R alpha, hFc Tag with the EC50 of 1.76ug/ml determined by ELISA.
The purity of Biotinylated Human IL-17R alpha is greater than 95% as determined by SEC-HPLC.
Biotinylated Human IL-17R alpha on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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