• Express System: HEK293
  • Product Tag: C-hFc (IgG1)
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Activity: The affinity constant of 42.04 nM as determined in SPR assay (Biacore T200).
  • Amino Acid Range: Gly24-Gly355
Catalog #ILR-HM223B
Price
Regular price $57800
Regular price Sale price $57800
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Size
Avantor VWR Fisher Scientific

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Biotinylated Human IL-23R Protein (Primary Amine Labeling) (ILR-HM223B) Summary

Product Description

 Recombinant Biotinylated Human IL-23R Protein (Primary Amine Labeling) is expressed from HEK293 with hFc (IgG1) tag at the C-terminus.It contains Gly24-Gly355.

Product Background

 Interleukin-23 (IL-23), a member of the IL-12 family of cytokines, is a heterodimeric cytokine. It is composed of subunits p40 (shared with IL-12) and p19 (an IL-12 p35-related subunit) and is secreted by several types of immune cells, such as natural killer cells and dendritic cells. The IL-23 receptor is composed of the subunit IL-12Rβ1 and the IL-23-specific subunit IL-23R. The binding of IL-23 to its specific cell surface receptor regulates a number of functions, including proliferation and differentiation of cells and secretion of cell factors.

Biotinylated Human IL-23R Protein (Primary Amine Labeling) (ILR-HM223B) Specifications/Details

Protein
 IL-23R
Synonyms
 IBD17; IL-23 R; IL-23 receptor;IL23R; IL23 receptor
Accession
Species
 Human
Biotinylated
 yes
Amino Acid Range
 Gly24-Gly355
Molecular Weight
 The protein has a predicted MW of 64.81 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Bis-Tris PAGE result.
Activity
 The affinity constant of 42.04 nM as determined in SPR assay (Biacore T200).
Product Tag
 C-hFc (IgG1)
Fluorophore
 Biotin-labeled
Expression System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE
Endotoxin
 Less than 1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Biotinylated Human IL-23R, hFc Avi Tag captured on CM5 Chip via Protein A can bind Human IL-23 alpha&IL-12 beta, His Tag with an affinity constant of 42.04 nM as determined in SPR assay (Biacore T200). Biotinylated Human IL-23R, hFc Avi Tag captured on CM5 Chip via Protein A can bind Human IL-23 alpha&IL-12 beta, His Tag with an affinity constant of 42.04 nM as determined in SPR assay (Biacore T200).
Biotinylated Human IL-23R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Biotinylated Human IL-23R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
Other Available Proteins:
Finding available proteins...