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Biotinylated Human IL-23R Protein (Primary Amine Labeling) (ILR-HM223B) Summary
Product Description |
Recombinant Biotinylated Human IL-23R Protein (Primary Amine Labeling) is expressed from HEK293 with hFc (IgG1) tag at the C-terminus.It contains Gly24-Gly355. |
Product Background |
Interleukin-23 (IL-23), a member of the IL-12 family of cytokines, is a heterodimeric cytokine. It is composed of subunits p40 (shared with IL-12) and p19 (an IL-12 p35-related subunit) and is secreted by several types of immune cells, such as natural killer cells and dendritic cells. The IL-23 receptor is composed of the subunit IL-12Rβ1 and the IL-23-specific subunit IL-23R. The binding of IL-23 to its specific cell surface receptor regulates a number of functions, including proliferation and differentiation of cells and secretion of cell factors. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Biotinylated Human IL-23R Protein (Primary Amine Labeling) (ILR-HM223B) Specifications/Details
Protein |
IL-23R |
Synonyms |
IBD17; IL-23 R; IL-23 receptor |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Gly24-Gly355 |
Molecular Weight |
The protein has a predicted MW of 64.81 kDa. Due to glycosylation, the protein migrates to 90-110 kDa based on Bis-Tris PAGE result. |
Activity |
The affinity constant of 42.04 nM as determined in SPR assay (Biacore T200). |
Product Tag |
C-hFc (IgG1) |
Fluorophore |
Biotin-labeled |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Biotinylated Human IL-23R, hFc Avi Tag captured on CM5 Chip via Protein A can bind Human IL-23 alpha&IL-12 beta, His Tag with an affinity constant of 42.04 nM as determined in SPR assay (Biacore T200). |
|
|
Biotinylated Human IL-23R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
Other Available Proteins:
Finding available proteins...
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