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Biotinylated Human Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer Protein (ITG-HM4ABB) Summary
Product Description |
Recombinant Biotinylated Human Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Tyr30-Thr1132 (ITGA2) and Gln21-Asp728 (ITGB1). |
Product Background |
The α2β1 integrin, also known as VLA-2, GPIa-IIa, CD49b, was first identified as an extracellular matrix receptor for collagens and/or laminins. It is now recognized that the α2β1 integrin serves as a receptor for many matrix and nonmatrix molecules. It plays a critical role in platelet function and homeostasis. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Biotinylated Human Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer Protein (ITG-HM4ABB) Specifications/Details
Protein |
Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer |
Synonyms |
α2β1; Integrin alpha A1 beta 1; alpha A1 beta 1; alpha A1; beta 1; ITGA1&ITGB1; ITGA&ITGB; VLA-2, GPIa-IIa, CD49b;Integrin alpha A1 β 1; alpha A1 β 1; β 1 |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Tyr30-Thr1132(ITGA2) & Gln21-Asp728(ITGB1) |
Molecular Weight |
The protein has a predicted MW of 128.45 kDa (ITGA2) and 83.19 kDa (ITGB1). Due to glycosylation, the protein migrates to 110-130 kDa and 140-160 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His-Avi |
Fluorophore |
Biotin-labeled |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Biotinylated Human ITGA2&ITGB1 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Biotinylated Human ITGA2&ITGB1 is greater than 95% as determined by SEC-HPLC. |
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