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Biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-HM447B) Summary
Product Description |
Recombinant Biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus of ITGA4.It contains Tyr34-Thr977(ITGA4) acidic tail and Glu20-His723(ITGB7) basic tail. |
Product Background |
Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery/Others |
Biotinylated Human Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer Protein (ITG-HM447B) Specifications/Details
Protein |
Integrin alpha 4 beta 7 (ITGA4&ITGB7) Heterodimer |
Synonyms |
Integrin alpha 4 beta 7; beta7; alpha 4; LPAM; ITGA4&ITGB7;Integrin alpha 4 β 7; β7 |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Tyr34-Thr977(ITGA4) acidic tail & Glu20-His723(ITGB7) basic tail |
Molecular Weight |
The protein has a predicted MW of 112.5 kDa (ITGA4) and 81.3 kDa (ITGB7). Due to glycosylation, the protein migrates to 68-72 kDa, 78-83 kDa, 110-120 kDa and 130-150 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Biotinylated Human ITGA4&ITGB7, His-Avi Tag at 2ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 2.6ng/ml determined by ELISA. |
Product Tag |
C-His-Avi |
Fluorophore |
Biotin-labeled |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS, 8% trehalose (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Biotinylated Human ITGA4&ITGB7, His-Avi Tag at 2ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-ITGA4 Antibody, hFc Tag with the EC50 of 2.6ng/ml determined by ELISA. |
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Biotinylated Human ITGA4&ITGB7 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
Other Available Proteins:
Finding available proteins...
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