Biotinylated Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein (ITG-HM4V3B)
Biotinylated Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein (ITG-HM4V3B)
Biotinylated Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein (ITG-HM4V3B)
Biotinylated Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein (ITG-HM4V3B)
  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Biotinylated Human ITGAV&ITGB3, His Tag at 0.5ug/ml (100ul/Well) on streptavidin (5ug/ml) precoated plate. Dose response curve for Anti-alpha V beta3 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: Phe31-Val992(ITGAV) acidic tail & Gly27-Asp718(ITGB3) basic tail
Catalog #ITG-HM4V3B
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Product Description
 Recombinant Biotinylated Human Integrin alpha V beta 3 (ITGAV&ITGB3) Heterodimer Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Phe31-Val992 (ITGAV) acidic tail & Gly27-Asp718 (ITGB3) basic tail.
Product Background
 ITGAV&ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling. ITGAV&ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling. ITGAV&ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling. ITGAV&ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling. ITGAV&ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling.
Product Category
 Recombinant Protein
Target
 ITGAV&ITGB3
Synonyms
 αVβ3; Integrin alpha V beta 3; beta3; alphaV; ITGAV&ITGB3;Integrin alpha V β 3; β3
Accession
Species
 Human
Biotinylated
 yes
Amino Acid Range
 Phe31-Val992(ITGAV) acidic tail & Gly27-Asp718(ITGB3) basic tail
Molecular Weight
 The protein has a predicted MW of 114 kDa (ITGAV) & 81.3 kDa (ITGB3). Due to glycosylation, the protein migrates to 100-160 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Biotinylated Human ITGAV&ITGB3, His Tag at 0.5ug/ml (100ul/Well) on streptavidin (5ug/ml) precoated plate. Dose response curve for Anti-alpha V beta3 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA. See testing image for detail.
Product Tag
 C-His-Avi
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Biotinylated Human ITGAV&ITGB3, His Tag at 0.5ug/ml (100ul/Well) on streptavidin (5ug/ml) precoated plate. Dose response curve for Anti-alpha V beta3 Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA.
Biotinylated Human ITGAV&ITGB3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Biotinylated Human ITGAV&ITGB3 is greater than 95% as determined by SEC-HPLC.

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