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Biotinylated Human Kv1.3 Nanodisc (KV1-HM10NB) Summary
Product Description |
Recombinant Biotinylated Human Kv1.3 Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Val575. |
Product Background |
Kv1.3 is a voltage gated potassium channel located in the plasma membrane, as well as at intracellular levels, such as mitochondria (mitoKv1.3), nucleus and Golgi apparatus. The plasma membrane channel has been shown to be important for cell proliferation, while the mitochondrial counterpart has been related to modulation of cell death. Moreover, altered expression of Kv1.3 was observed in various tumors and Kv1.3 seems to be involved in development and progression of various cancerous forms. |
Product Category |
Recombinant Protein / Antibody discovery / Multiple transmembrane proteins / Nanodisc |
Biotinylated Human Kv1.3 Nanodisc (KV1-HM10NB) Specifications/Details
Protein |
Kv1.3 |
Synonyms |
HGK5; HLK3; HPCN3; KCNA3 |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Met1-Val575 |
Molecular Weight |
The protein has a predicted MW of 76.79 kDa. |
Activity |
Immobilized Biotinylated Human Kv1.3 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-Kv1.3 Antibody, hFc Tag with the EC50 of 0.11ug/ml determined by ELISA. The affinity constant of 0.78 nM as determined in SPR assay (Biacore T200). |
Product Tag |
C-His |
Fluorophore |
Biotin-labeled |
Expression System |
HEK293 |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS, 200mM L-arginine (pH 7.4). |
Stability And Storage |
Valid for 6 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Biotinylated Human Kv1.3 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-Kv1.3 Antibody, hFc Tag with an affinity constant of 0.78 nM as determined in SPR assay (Biacore T200). |
|
|
Immobilized Biotinylated Human Kv1.3 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-Kv1.3 Antibody, hFc Tag with the EC50 of 0.11ug/ml determined by ELISA. |
Other Available Proteins:
Finding available proteins...
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