Name: Biotinylated Human M-CSF R/CSF1R/CD115 Protein (CSF-HM41RB)
Brand: KactusBio
SKU: CSF-HM41RB-100UG
Price: 525.0 USD
Availability: InStock

Biotinylated Human M-CSF R/CSF1R/CD115 Protein (CSF-HM41RB)

Biotinylated Human M-CSF R, His-Avi Tag immobilized on CM5 Chip can bind Human M-CSF, No Tag with an affinity constant of 0.81 uM as determined in SPR assay (Biacore T200).

Immobilized Biotinylated Human M-CSF R , His Tag at 0.5ug/ml(100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-M-CSF R Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA (QC Test).

Biotinylated Human M-CSF R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Biotinylated Human M-CSF R is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Biotinylated Human M-CSF R , His Tag at 0.5ug/ml(100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-M-CSF R Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA (QC Test). The affinity constant of 0.81 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Ile20-Glu512

Catalog #CSF-HM41RB

Size

100UG

500UG

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Product Description	Recombinant Biotinylated Human M-CSF R/CSF1R/CD115 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Ile20-Glu512.
Product Background	CSF1R also known as M-CSF receptor, the product of the c-fms proto-oncogene, is a member of the type III subfamily of receptor tyrosine kinases that also includes receptors for SCF and PDGF. These receptors each contain five immunoglobulin-like domains in their extracellular domain (ECD) and a split kinase domain in their intracellular region.CSF1R is tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes.
Product Category	Recombinant Protein / Antibody discovery

Protein	M-CSF R/CSF1R/CD115
Synonyms	CD115; CSF1R; CSF-1-R; CSFR; FMSFIM2; M-CSF R; MCSFR; M-CSFR; C-FMS; FIM2; FMS; HDLS
Accession	P07333-1
Species	Human
Biotinylated	yes
Amino Acid Range	Ile20-Glu512
Molecular Weight	The protein has a predicted MW of 57.4 kDa. Due to glycosylation, the protein migrates to 75-105 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Biotinylated Human M-CSF R , His Tag at 0.5ug/ml(100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-M-CSF R Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA (QC Test). The affinity constant of 0.81 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Biotinylated Human M-CSF R, His-Avi Tag immobilized on CM5 Chip can bind Human M-CSF, No Tag with an affinity constant of 0.81 uM as determined in SPR assay (Biacore T200).
	Immobilized Biotinylated Human M-CSF R , His Tag at 0.5ug/ml(100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-M-CSF R Antibody, hFc Tag with the EC50 of 4.2ng/ml determined by ELISA (QC Test).
	Biotinylated Human M-CSF R on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Biotinylated Human M-CSF R is greater than 95% as determined by SEC-HPLC.