Name: Biotinylated Human PD-L2/B7-DC Protein (PDL-HM402B)
Brand: KactusBio
SKU: PDL-HM402B-100UG
Price: 525.0 USD
Availability: InStock

Biotinylated Human PD-L2/B7-DC Protein (PDL-HM402B)

Human PD-1, hFc Tag captured on CM5 Chip via Protein A can bind Biotinylated Human PD-L2, His-Avi Tag with an affinity constant of 0.344 uM as determined in SPR assay (Biacore T200).

Biotinylated Human PD-L2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Biotinylated Human PD-L2 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 0.344 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Leu20-Thr220

Catalog #PDL-HM402B

Size

100UG

500UG

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Product Description	Recombinant Biotinylated Human PD-L2/B7-DC Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Leu20-Thr220.
Product Background	PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals.
Product Category	Recombinant Protein / Antibody discovery / Immune checkpoint proteins

Protein	PD-L2/B7-DC
Synonyms	PDL2; PD-L2; Butyrophilin B7-DC; CD273, PDCD1 ligand 2; PDCD1L2; PDCD1LG2; B7DC; bA574F11.2; Btdc
Accession	Q9BQ51-1
Species	Human
Biotinylated	yes
Amino Acid Range	Leu20-Thr220
Molecular Weight	The protein has a predicted MW of 25.3 kDa. Due to glycosylation, the protein migrates to 40-52 kDa based on Bis-Tris PAGE result.
Activity	The affinity constant of 0.344 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Human PD-1, hFc Tag captured on CM5 Chip via Protein A can bind Biotinylated Human PD-L2, His-Avi Tag with an affinity constant of 0.344 uM as determined in SPR assay (Biacore T200).
	Biotinylated Human PD-L2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Biotinylated Human PD-L2 is greater than 95% as determined by SEC-HPLC.