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Biotinylated Human PRLR Protein, Ultra Low Endotoxin (PLR-HM401B-UL) Summary
Product Description |
Recombinant Biotinylated Human PRLR Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Gln25-Asp234. |
Product Background |
Prolactin receptor (PRLR) is highly expressed in a subset of human breast cancer and prostate cancer, which makes it a potential target for cancer treatment. In clinical trials, the blockade of PRLR was shown to be safe but with poor efficacy. It is therefore urgent to develop new therapies against PRLR target. Bispecific antibodies (BsAbs) could guide immune cells toward tumor cells, and produced remarkable effects in some cancers. |
Product Category |
Recombinant Protein / Antibody discovery / ADC targets |
Biotinylated Human PRLR Protein, Ultra Low Endotoxin (PLR-HM401B-UL) Specifications/Details
Protein |
PRLR |
Synonyms |
PRL-R; HPRL; MFAB; Prolactin R |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Gln25-Asp234 |
Molecular Weight |
The protein has a predicted MW of 27.32 kDa. Due to glycosylation, the protein migrates to 32-40 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Biotinylated Human PRLR, His Avi Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-PRLR Antibody, hFc Tag with the EC50 of 7.2ng/ml determined by ELISA. |
Product Tag |
C-His-Avi |
Fluorophore |
Biotin-labeled |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 0.01 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22 um filtered solution in 50mM Tris, 150mM NaCl (pH 7.5). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Biotinylated Human PRLR, His Avi Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-PRLR Antibody, hFc Tag with the EC50 of 7.2ng/ml determined by ELISA. |
|
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Biotinylated Human PRLR on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Biotinylated Human PRLR is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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