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Biotinylated Human SEZ6 Sushi4 Domain Protein (SEZ-HM40DB) Summary
Product Description |
Recombinant Biotinylated Human SEZ6 Sushi4 Domain Protein is expressed from HEK293 with His tag and Avi tag at the C-terminus.It contains Leu750-Cys813. |
Product Background |
Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. |
Product Category |
Recombinant Protein / Antibody discovery / ADC targets |
Biotinylated Human SEZ6 Sushi4 Domain Protein (SEZ-HM40DB) Specifications/Details
Protein |
SEZ6 |
Synonyms |
SEZ-6; SEZ6; BSRPC; BSRP-C |
Accession |
|
Species |
Human |
Biotinylated |
yes |
Amino Acid Range |
Leu750-Cys813 |
Molecular Weight |
The protein has a predicted MW of 10.42 kDa. Due to glycosylation, the protein migrates to 11-15 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Biotinylated Human SEZ6 Sushi4 Domain, His Avi Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-SEZ6 Sushi4 Antibody, hFc Tag with the EC50 of 1.9ng/ml determined by ELISA. |
Product Tag |
C-His-Avi |
Fluorophore |
Biotin-labeled |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
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Immobilized Biotinylated Human SEZ6 Sushi4 Domain, His Avi Tag at 0.5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-SEZ6 Sushi4 Antibody, hFc Tag with the EC50 of 1.9ng/ml determined by ELISA. |
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Biotinylated Human SEZ6 Sushi4 Domain on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Biotinylated Human SEZ6 Sushi4 Domain is greater than 95% as determined by SEC-HPLC. |
Other Available Proteins:
Finding available proteins...
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