Name: Biotinylated Human TIM-3/HAVCR2 Protein (TIM-HM431B)
Brand: KactusBio
SKU: TIM-HM431B-100UG
Price: 577.5 USD
Availability: InStock

Biotinylated Human TIM-3/HAVCR2 Protein (TIM-HM431B)

Immobilized Anti-TIM-3 Antibody, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human TIM-3, His Tag with the EC50 of 11.3ng/ml determined by ELISA.

Biotinylated Human TIM-3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Biotinylated Human TIM-3 is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Anti-TIM-3 Antibody, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human TIM-3, His Tag with the EC50 of 11.3ng/ml determined by ELISA. See testing image for detail.
Amino Acid Range: Ser22-Arg200

Catalog #TIM-HM431B

Size

100UG

500UG

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Product Description	Recombinant Biotinylated Human TIM-3/HAVCR2 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Ser22-Arg200.
Product Background	Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 gene.TIM3 is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8 T-cell exhaustion. TIM3 has also been shown as a CD4 Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.
Product Category	Recombinant Protein / Antibody discovery / Immune checkpoint proteins

Protein	TIM-3/HAVCR2
Synonyms	CD366; TIM3; TIM-3; TIMD-3; TIM 3;-FLJ14428; HAVCR2; KIM3
Accession	Q8TDQ0-1
Species	Human
Biotinylated	yes
Amino Acid Range	Ser22-Arg200
Molecular Weight	The protein has a predicted MW of 22.8 kDa. Due to glycosylation, the protein migrates to 45-50 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Anti-TIM-3 Antibody, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human TIM-3, His Tag with the EC50 of 11.3ng/ml determined by ELISA. See testing image for detail.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 24 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Anti-TIM-3 Antibody, hFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human TIM-3, His Tag with the EC50 of 11.3ng/ml determined by ELISA.
	Biotinylated Human TIM-3 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Biotinylated Human TIM-3 is greater than 95% as determined by SEC-HPLC.