Biotinylated Human TREM2 Protein (TRM-HM401B)
Biotinylated Human TREM2 Protein (TRM-HM401B)
Biotinylated Human TREM2 Protein (TRM-HM401B)
  • Express System: HEK293
  • Product Tag: C-His-Avi
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Activity: Immobilized Biotinylated Human TREM2, His Tag at 1ug/ml (100ul/Well) on streptavidin (5ug/ml) precoated plate. Dose response curve for Anti-TREM2 Antibody, hFc Tag with the EC50 of 5.8ng/ml determined by ELISA. See testing image for detail.
  • Amino Acid Range: His19-Ser174
Catalog #TRM-HM401B
Regular price $525.00
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Product Description
Recombinant Biotinylated Human TREM2 Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains His19-Ser174.
Product Background
TREM-2 (Triggering Receptor Expressed on Myeloid cells-2) is a 35 kDa type I transmembrane member of the TREM family and Ig superfamily. Mature human TREM-2- consists of a 156 amino acid (aa) extracellular domain (ECD) with one V-type Ig-like domain, a 21 aa transmembrane (TM) domain, and a 35 aa cytoplasmic tail. TREM-2 forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding (PubMed:10799849). Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia.
Product Category
Recombinant Protein
Target
TREM2
Synonyms
PLOSL2; TREM2; TREM-2; Trem2a; Trem2b; Trem2c
Accession
Species
Human
Biotinylated
yes
Amino Acid Range
His19-Ser174
Molecular Weight
The protein has a predicted MW of 20.3 kDa. Due to glycosylation, the protein migrates to 30-45 kDa based on Bis-Tris PAGE result.
Activity
Immobilized Biotinylated Human TREM2, His Tag at 1ug/ml (100ul/Well) on streptavidin (5ug/ml) precoated plate. Dose response curve for Anti-TREM2 Antibody, hFc Tag with the EC50 of 5.8ng/ml determined by ELISA. See testing image for detail.
Product Tag
C-His-Avi
Express System
HEK293
Purity
> 95% as determined by Bis-Tris PAGE
Endotoxin
Less than 1EU per ug by the LAL method.
Form
Lyophilized
Shipping
Shipped at ambient temperature.
Formulation
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Immobilized Biotinylated Human TREM2, His Tag at 1ug/ml (100ul/Well) on streptavidin (5ug/ml) precoated plate. Dose response curve for Anti-TREM2 Antibody, hFc Tag with the EC50 of 5.8ng/ml determined by ELISA.
Biotinylated Human TREM2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

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