Biotinylated Mouse FGFR3 alpha (IIIb) Protein (Primary Amine Labeling) (FGF-MM43BB)
  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE
  • Amino Acid Range: Pro22-Val349
Catalog #FGF-MM43BB
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Product Description
 Recombinant Biotinylated Mouse FGFR3 alpha (IIIb) Protein (Primary Amine Labeling) is expressed from HEK293 with His tag at the C-terminus.It contains Pro22-Val349.
Product Background
 Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts.
Product Category
 Recombinant Protein
Target
 FGFR3 alpha (IIIb)
Accession
Species
 Mouse
Biotinylated
 yes
Amino Acid Range
 Pro22-Val349
Molecular Weight
 The protein has a predicted MW of 37.09 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Bis-Tris PAGE result.
Product Tag
 C-His
Express System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE
Endotoxin
 Less than 1EU per ug by the LAL method.
Form
 Lyophilized
Shipping
 Shipped at ambient temperature.
Formulation
 Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution
 Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage
 Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Biotinylated Mouse FGFR3 alpha (IIIb) on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

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