Name: Biotinylated Rat FcRn Protein (FRN-RM401B)
Brand: KactusBio
SKU: FRN-RM401B-100UG
Price: 577.5 USD
Availability: InStock

Biotinylated Rat FcRn Protein (FRN-RM401B)

Biotinylated Rat FcRn, His Tag- captured on CM5 Chip via Anti-His Antibody can bind Trastuzumab with an affinity constant of 5.08 nM as determined in SPR assay (Biacore T200).

Biotinylated Rat FcRn on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Biotinylated Rat FcRn is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His-Avi
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 5.08 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Ala23-Ser298(FCGRT) & Ile21-Met119(B2M)

Catalog #FRN-RM401B

Size

100UG

500UG

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Product Description	Recombinant Biotinylated Rat FcRn Protein is expressed from HEK293 with His tag and Avi Tag at the C-terminus of FCGRT.It contains Ala23-Ser298(FCGRT) and Ile21-Met119(B2M).
Product Background	The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells.FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51, and p14 , and forms an MHC class I-like heterodimer.
Product Category	Recombinant Protein / Antibody discovery / Fc receptors

Protein	FcRn
Synonyms	FcRn alpha chain; FCGRT; FCRN; FCGRT&B2M
Accession	P13599(FCGRT)&P07151(B2M)
Species	Rat
Biotinylated	yes
Amino Acid Range	Ala23-Ser298(FCGRT) & Ile21-Met119(B2M)
Molecular Weight	The protein has a predicted MW of 33.9 kDa (FCGRT) and 11.63 kDa (B2M). Due to glycosylation, the protein migrates to 45-60 kDa (FCGRT) and 12-14 kDa (B2M) based on Bis-Tris PAGE result.
Activity	The affinity constant of 5.08 nM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His-Avi
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Biotinylated Rat FcRn, His Tag- captured on CM5 Chip via Anti-His Antibody can bind Trastuzumab with an affinity constant of 5.08 nM as determined in SPR assay (Biacore T200).
	Biotinylated Rat FcRn on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Biotinylated Rat FcRn is greater than 95% as determined by SEC-HPLC.