Product Description |
Recombinant Biotinylated Rat FcRn Protein is expressed from HEK293 with His tag and Avi Tag at the C-terminus.It contains Ala23-Ser298(FCGRT) and Ile21-Met119(B2M). |
Product Background |
The neonatal Fc receptor (FCRN) is an approximately 45 kDa transmembrane glycoprotein with structural homology to MHC class I proteins. It is widely expressed in endothelial and epithelial cells and plays an important role in IgG homeostasis and antigen presentation by dendritic cells.FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51, and p14 , and forms an MHC class I-like heterodimer. |
Product Category |
Recombinant Protein / Antibody discovery / Fc receptors |
Protein |
FcRn |
Synonyms |
FcRn alpha chain; FCGRT; FCRN; FCGRT&B2M |
Accession |
|
Species |
Rat |
Biotinylated |
yes |
Amino Acid Range |
Ala23-Ser298(FCGRT) & Ile21-Met119(B2M) |
Molecular Weight |
The protein has a predicted MW of 33.9 kDa (FCGRT) and 11.63 kDa (B2M). Due to glycosylation, the protein migrates to 45-60 kDa (FCGRT) and 12-14 kDa (B2M) based on Bis-Tris PAGE result. |
Product Tag |
C-His-Avi |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
|
|
Biotinylated Rat FcRn on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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The purity of Biotinylated Rat FcRn is greater than 95% as determined by SEC-HPLC. |
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