Product Description |
Recombinant Canine AFP Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Arg19-Val609. |
Product Background |
Alpha-fetoprotein is a shuttle protein that delivers nutrients through receptor-mediated endocytosis to embryotic cells. In adults, alpha-fetoprotein can shuttle drugs into alpha-fetoprotein receptor-positive myeloid-derived suppressor, regenerating and also cancer cells. Drugs with high-binding affinity to alpha-fetoprotein can activate or deplete targeted cells. Myeloid-derived suppressor cells activation leads to immune suppression that can be used for treating autoimmune diseases. |
Product Category |
Recombinant Protein |
Target |
AFP |
Accession |
|
Species |
Canine |
Biotinylated |
no |
Amino Acid Range |
Arg19-Val609 |
Molecular Weight |
The protein has a predicted MW of 67.71 kDa. Due to glycosylation, the protein migrates to 68-70 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water. |
Stability And Storage |
Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. |
|
|
Canine AFP on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
The purity of Canine AFP is greater than 95% as determined by SEC-HPLC. |
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