Product Description |
Recombinant Canine BMPR1A/ALK-3 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gln24-Arg152. |
Product Background |
The type IA bone morphogenetic protein receptor (Bmpr1a), encoded by 11 exons and spanning about 40 kb on chromosome 14 in mice and chromosome 10 in human (Derynck & Feng, 1997; Mishina, Hanks, Miura, Tallquist, & Behringer, 2002), is an essential receptor for BMP signaling. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Protein |
BMPR1A/ALK-3 |
Synonyms |
BMPR1A; ALK-3; ALK3; ALK 3 |
Accession |
|
Species |
Canine |
Biotinylated |
no |
Amino Acid Range |
Gln24-Arg152 |
Molecular Weight |
The protein has a predicted MW of 40.94 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Bis-Tris PAGE result. |
Product Tag |
C-hFc |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Form |
Lyophilized |
Shipping |
Shipped at ambient temperature. |
Formulation |
Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
Reconstitution |
Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
Stability And Storage |
-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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|
Canine BMPR1A on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
|
|
Measured by its ability to inhibit rhBMP4-induced alkaline phosphatase production by ATDC5 cells. The ED50-for this effect is typically 0.5 - 2.5 ug/mL in the presence of 50 ng/mL of recombinant human BMP4. |
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The purity of Canine BMPR1A is greater than 95% as determined by SEC-HPLC. |
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