• Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
  • Activity: Immobilized Canine IL-2 R alpha, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-2, His Avi Tag (Cat. IL2-HM401B) with the EC50 of 18.9ng/ml determined by ELISA.
  • Amino Acid Range: Asp22-Gln237
Catalog #CD5-DM125
Price
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Size
Avantor VWR Fisher Scientific

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Canine IL-2 R alpha/CD25 Protein (CD5-DM125) Summary

Product Description

 Recombinant Canine IL-2 R alpha/CD25 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Asp22-Gln237.

Product Background

 IL-2 receptor alpha (IL-2 R alpha), also known as Tac antigen and as CD25, was initially identified as a 55 kDa membrane glycoprotein that is capable of binding IL‑2.eceptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells.

Product Category

 Recombinant Protein / Antibody discovery / ADC targets

Canine IL-2 R alpha/CD25 Protein (CD5-DM125) Specifications/Details

Protein
 IL-2 R alpha/CD25
Synonyms
 CD25; IDDM10; IL-2 R alpha; IL2R; IL2RA; p55; TCGFR
Accession
Species
 Canine
Biotinylated
 no
Amino Acid Range
 Asp22-Gln237
Molecular Weight
 The protein has a predicted MW of 26.1 kDa. Due to glycosylation, the protein migrates to 52-65 kDa based on Bis-Tris PAGE result.
Activity
 Immobilized Canine IL-2 R alpha, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-2, His Avi Tag (Cat. IL2-HM401B) with the EC50 of 18.9ng/ml determined by ELISA.
Product Tag
 C-His

Fluorophore

 Unconjugated
Expression System
 HEK293
Purity
 > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin
 Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form
 Liquid
Shipping
 Shipped with dry ice.
Formulation
 Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage
 Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

Immobilized Canine IL-2 R alpha, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-2, His Avi Tag (Cat. IL2-HM401B) with the EC50 of 18.9ng/ml determined by ELISA. Immobilized Canine IL-2 R alpha, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-2, His Avi Tag (Cat. IL2-HM401B) with the EC50 of 18.9ng/ml determined by ELISA.
Canine IL-2 R alpha on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. Canine IL-2 R alpha on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
The purity of Canine IL-2 R alpha is greater than 95% as determined by SEC-HPLC. The purity of Canine IL-2 R alpha is greater than 95% as determined by SEC-HPLC.
Other Available Proteins:
Finding available proteins...
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