Canine IL-23R Protein (ILR-DM123)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Activity: Immobilized Canine IL-23R, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-23 alpha&IL-12 beta, His Tag with the EC50 of 2.7ug/ml determined by ELISA. See testing image for detail.
Exact Sequence: Gly24-Asp354

Catalog: ILR-DM123

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Product Description	Recombinant Canine IL-23R Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gly24-Asp354.
Product Background	Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R).This receptor associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.
Product Category	Recombinant Protein

Target	IL-23R
Gene/Protein ID	A0A8I3PXL0
Species	Canine
Exact Sequence	Gly24-Asp354
Molecular Weight	The protein has a predicted MW of 39.31 kDa. Due to glycosylation, the protein migrates to 55-70 kDa based on Tris-Bis PAGE result.
Activity	Immobilized Canine IL-23R, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-23 alpha&IL-12 beta, His Tag with the EC50 of 2.7ug/ml determined by ELISA. See testing image for detail.
Product Tag	C-His
Express System	HEK293
Purity	> 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

	Immobilized Canine IL-23R, His Tag at 5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Human IL-23 alpha&IL-12 beta, His Tag with the EC50 of 2.7ug/ml determined by ELISA.
	The purity of Canine IL-23R is greater than 95% as determined by SEC-HPLC.
	Canine IL-23R on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.