Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A3 (KVAELVHFL) Monomer Protein (MHC-HM105)
Catalog: MHC-HM105
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Product Description | Recombinant Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A3 (KVAELVHFL) Monomer Protein is expressed from HEK293 with His tag at the C-terminus.It contains Gly25-Thr206 (Human HLA-A*02:01 α1&α2) and Asp207-Glu299 (Mouse H-2Ld α3), Ile21-Met119 (mB2M) and KVAELVHFL peptide. |
Product Background |
Melanoma antigen family A, 3 (MAGE-A3) is a cancer-testis antigen whose expression has been demonstrated in a wide array of malignancies including melanoma, brain, breast, lung and ovarian cancer. In addition, its ability to elicit spontaneous humoral and cellular immune responses has been shown in cancer patients. |
Product Category |
Recombinant Protein |
Target |
HLA-A*02:01 (mα3) &mB2M&MAGE-A3 (KVAELVHFL) Monomer |
Accession | |
MHC Form | Monomer |
Allele | HLA-A*02:01 |
Species |
Human&Mouse |
Amino Acid Range |
Gly25-Thr206(Human HLA-A*02:01 α1&α2) & Asp207-Glu299(Mouse H-2Ld α3), Ile21-Met119(mB2M) and KVAELVHFL peptide |
Molecular Weight | The protein has a predicted MW of 48.00 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Tris-Bis PAGE result. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity | > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Liquid |
Shipping | Shipped with dry ice. |
Formulation | Supplied as 0.22 um filtered solution in PBS (pH 7.4). |
Stability And Storage | Valid for 12 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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