Name: Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer Protein (MHC-HM106)
Brand: KactusBio
SKU: MHC-HM106-100UG
Price: 310.0 USD
Availability: InStock

Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer Protein (MHC-HM106)

HLA-A*02:01&B2M&MAGE-A4 (KVLEHVVRV) TCR immobilized on CM5 Chip can bind Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer, His Tag with an affinity constant of 4.76 uM as determined in SPR assay (Biacore T200).

Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

The purity of Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer is greater than 95% as determined by SEC-HPLC.

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: The affinity constant of 4.76 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Amino Acid Range: Gly25-Thr206(Human HLA-A*02:01 α1&α2) & Asp207-Glu299(Mouse H-2Ld α3), Ile21-Met119(mB2M) and KVLEHVVRV peptide

Catalog #MHC-HM106

Size

100UG

500UG

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Product Description	Recombinant Chimeric HLA-A02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer Protein is expressed from HEK293 with His tag at the C-terminus.It contains Gly25-Thr206 (Human HLA-A02:01 α1&α2) and Asp207-Glu299 (Mouse H-2Ld α3), Ile21-Met119 (mB2M) and KVLEHVVRV peptide.
Product Background	MAGE-A4 and MAGE-A8 are type I membes of the melanoma associated antigen (MAGE) family. The MAGE family is a large, highly conserved group of proteins that share a common MAGE homology domain. Both MAGE-A4 and MAGE-A8 antigen-presenting peptides can be presented by HLA-A*02:01.
Product Category	Recombinant Protein / Antibody discovery / MHC

Protein	HLA-A*02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer
Synonyms	MAGE-A4; MAGE-A8;
MHC Form	Monomer
Allele	HLA-A*02:01
Accession	A0A140T913(Human HLA-A*02:01 α1&α2)&P01897(Mouse H-2Ld α3)&P01887(Mouse B2M)&KVLEHVVRV
Species	Human
Biotinylated	no
Amino Acid Range	Gly25-Thr206(Human HLA-A*02:01 α1&α2) & Asp207-Glu299(Mouse H-2Ld α3), Ile21-Met119(mB2M) and KVLEHVVRV peptide
Molecular Weight	The protein has a predicted MW of 48.00 kDa. Due to glycosylation, the protein migrates to 50-65 kDa based on Bis-Tris PAGE result.
Activity	The affinity constant of 4.76 uM as determined in SPR assay (Biacore T200). See testing image for detail.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in PBS (pH 7.4).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	HLA-A02:01&B2M&MAGE-A4 (KVLEHVVRV) TCR immobilized on CM5 Chip can bind Chimeric HLA-A02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer, His Tag with an affinity constant of 4.76 uM as determined in SPR assay (Biacore T200).
	Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Chimeric HLA-A*02:01 (mα3) &mB2M&MAGE-A4 (KVLEHVVRV) Monomer is greater than 95% as determined by SEC-HPLC.