Cynomolgus ALK-1/ACVRL1 Protein (ALK-CM101)

  • Express System: HEK293
  • Product Tag: C-His
  • Purity: > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
  • Amino Acid Range: Asp22-Gln118

Catalog: ALK-CM101

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Product Description Recombinant Cynomolgus ALK-1/ACVRL1 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Asp22-Gln118.

Product Background

Activin receptor-like kinase 1 (ALK1)-mediated endothelial cell signalling in response to bone morphogenetic protein 9 (BMP9) and BMP10 is of significant importance in cardiovascular disease and cancer. Structural analyses reveal a tripartite recognition mechanism that defines BMP9 and BMP10 specificity for ALK1, and predict that crossveinless 2 is not an inhibitor of BMP9, which is confirmed by experimental evidence.

Product Category

Recombinant Protein

Target

ALK-1/ACVRL1
Accession

Species

Cynomolgus

Amino Acid Range

Asp22-Gln118
Molecular Weight The protein has a predicted MW of 11.86 kDa. Due to glycosylation, the protein migrates to 25-35 kDa based on Tris-Bis PAGE result.

Product Tag

C-His

Express System

HEK293
Purity > 95% as determined by Tris-Bis PAGE;> 95% as determined by HPLC
Endotoxin Less than 1EU per ug by the LAL method.
Form Lyophilized
Shipping Shipped at ambient temperature.
Formulation Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage Reconstituted protein stable at -80°C for 12 months, 4°C for 1 week. Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
The purity of Cynomolgus ALK-1 is greater than 95% as determined by SEC-HPLC.
Cynomolgus ALK-1 on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.

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