Name: Cynomolgus AMIGO2 Protein (AMI-CM102)
Brand: KactusBio
SKU: AMI-CM102-100UG
Price: 315.0 USD
Availability: InStock

Catalog #AMI-CM102

Size

100UG

500UG

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Product Description	Recombinant Cynomolgus AMIGO2 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Val39-Thr397.
Product Background	Bromodomain and extraterminal domain inhibitors (BETi) represent promising therapeutic agents for metastatic melanoma, yet their mechanism of action remains unclear. Here we interrogated the transcriptional effects of BETi and identified AMIGO2, a transmembrane molecule, as a BET target gene essential for melanoma cell survival. AMIGO2 is upregulated in melanoma cells and tissues compared to human melanocytes and nevi, and AMIGO2 silencing in melanoma cells induces G1/S arrest followed by apoptosis.
Product Category	Recombinant Protein / Antibody discovery

Protein	AMIGO2
Synonyms	Amphotein-induced protein 2; AMIGO-2; Alivin-1; DEGA; AMIGO2; ALI1; alivin 1
Accession	G7PHN7
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Val39-Thr397
Molecular Weight	The protein has a predicted MW of 41.97 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Product Tag	C-His
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Centrifuge the tube before opening. Reconstituting to a concentration more than 100 ug/ml is recommended. Dissolve the lyophilized protein in distilled water.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Cynomolgus AMIGO2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Cynomolgus AMIGO2 is greater than 95% as determined by SEC-HPLC.