Name: Cynomolgus BDCA-2 Protein (BCA-CM302)
Brand: KactusBio
SKU: BCA-CM302-100UG
Price: 346.5 USD
Availability: InStock

Express System: HEK293
Product Tag: N-mFc
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Immobilized Cynomolgus BDCA-2, mFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-BDCA-2 Antibody, hFc Tag with the EC50 of 15.1ng/ml determined by ELISA (QC Test).
Amino Acid Range: Tyr48-Ile212

Catalog #BCA-CM302

Size

100UG

500UG

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Cynomolgus BDCA-2 Protein (BCA-CM302) Summary

Product Description	Recombinant Cynomolgus BDCA-2 Protein is expressed from HEK293 with mFc (IgG2a) tag at the N-Terminus.It contains Tyr48-Ile212.
Product Background	BDCA-2 is a novel type II C-type lectin specifically expressed by plasmacytoid dendritic cells (PDCs) that can internalize antigen for presentation to T cells. Furthermore, signaling via BDCA-2 may play a role in switching from interferon (IFN)-α/β-controlled to interleukin (IL)-12-controlled immune response pathways, as triggering of BDCA-2 potently inhibits secretion of IFN-α/β by PDCs and thereby promotes IL-12 p70 production in PDCs and other cells.
Product Category	Recombinant Protein / Antibody discovery / Antibody discovery/Others

Cynomolgus BDCA-2 Protein (BCA-CM302) Specifications/Details

Protein	BDCA-2
Synonyms	BDCA-2; BDCA2; CLECSF11; CLECSF7; DLEC; HECL; CLEC4C; CD303;
Accession	A0A2K5UWP4
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Tyr48-Ile212
Molecular Weight	The protein has a predicted MW of 46.00 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Activity	Immobilized Cynomolgus BDCA-2, mFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-BDCA-2 Antibody, hFc Tag with the EC50 of 15.1ng/ml determined by ELISA (QC Test).
Product Tag	N-mFc
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 1 EU per ug by the LAL method.

Form	Lyophilized
Shipping	Shipped at ambient temperature.
Formulation	Lyophilized from 0.22 um filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization.
Reconstitution	Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 ug or less, at 1mg/ml for 500ug or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking.
Stability And Storage	-20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

	Immobilized Cynomolgus BDCA-2, mFc Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-BDCA-2 Antibody, hFc Tag with the EC50 of 15.1ng/ml determined by ELISA (QC Test).
	Cynomolgus BDCA-2 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	Loaded Anti-BDCA-2 Antibody, hFc Tag on HFC-Biosensor can bind Cynomolgus BDCA-2, mFc Tag with an affinity constant of 0.32 nM as determined in BLI assay .
	The purity of Cynomolgus BDCA-2 is greater than 95% as determined by SEC-HPLC.

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