Cynomolgus c-MPL/Thrombopoietin R Protein (MPL-CM101)
Catalog: MPL-CM101
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Product Description | Recombinant Cynomolgus c-MPL/Thrombopoietin R Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln22-Thr489. |
Product Background |
The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice.MPLV (for myeloproliferative leukemia virus) has transduced a truncated and constitutively activated form of the c-mpl receptor chain. High levels of c-mpl expression were detected in 45% of acute myeloid leukemia (AML). No correlation was found between c-mpl expression and the French-American-British classification subtype of AML. |
Product Category |
Recombinant Protein |
Target |
c-MPL/Thrombopoietin R |
Accession | |
Species |
Cynomolgus |
Amino Acid Range |
Gln22-Thr489 |
Molecular Weight | The protein has a predicted MW of 53.48 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Tris-Bis PAGE result. |
Activity |
Immobilized Cynomolgus c-MPL, His Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Anti-C-MPL Antibody, hFc Tag with the EC50 of 2.3ng/ml determined by ELISA. See testing image for detail. |
Product Tag |
C-His |
Express System |
HEK293 |
Purity | > 95% as determined by Tris-Bis PAGE |
Endotoxin | Less than 1EU per ug by the LAL method. |
Form | Liquid |
Shipping | Shipped with dry ice. |
Formulation | Supplied as 0.22um filtered solution in 20mM Tris, 500mM NaCl, 3mM DTT, 10% Glycerol (pH 7.5). |
Stability And Storage | Valid for 12 months from date of receipt when stored at -80°C.;Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
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