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Cynomolgus c-MPL/Thrombopoietin R Protein (MPL-CM101) Summary
Product Description |
Recombinant Cynomolgus c-MPL/Thrombopoietin R Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Gln22-Thr489. |
Product Background |
The c-mpl gene encodes a member of the hematopoietic cytokine receptor superfamily. This gene was discovered through the study of a murine retrovirus which induces an acute myeloproliferative syndrome in mice.MPLV (for myeloproliferative leukemia virus) has transduced a truncated and constitutively activated form of the c-mpl receptor chain. High levels of c-mpl expression were detected in 45% of acute myeloid leukemia (AML). No correlation was found between c-mpl expression and the French-American-British classification subtype of AML. |
Product Category |
Recombinant Protein / Antibody discovery / Antibody discovery | Others |
Cynomolgus c-MPL/Thrombopoietin R Protein (MPL-CM101) Specifications/Details
Protein |
c-MPL/Thrombopoietin R |
Synonyms |
TPO-R; CD110; MPL; c-Mpl; MPLV; K12 |
Accession |
|
Species |
Cynomolgus |
Biotinylated |
no |
Amino Acid Range |
Gln22-Thr489 |
Molecular Weight |
The protein has a predicted MW of 53.48 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result. |
Activity |
Immobilized Cynomolgus c-MPL, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-C-MPL Antibody, hFc Tag with the EC50 of 3.0ng/ml determined by ELISA (QC Test). |
Product Tag |
C-His |
Fluorophore |
Unconjugated |
Expression System |
HEK293 |
Purity |
> 95% as determined by Bis-Tris PAGE |
Endotoxin |
Less than 1 EU per ug by the LAL method. |
Shipping, Reconstitution, & Storage
Form |
Liquid |
Shipping |
Shipped with dry ice. |
Formulation |
Supplied as 0.22um filtered solution in 20mM Tris, 500mM NaCl, 3mM DTT, 10% Glycerol (pH 7.5). |
Stability And Storage |
Valid for 12 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
Validation Images
|
|
Immobilized Cynomolgus c-MPL, His Tag at 1ug/ml (100ul/well) on the plate. Dose response curve for Anti-C-MPL Antibody, hFc Tag with the EC50 of 3.0ng/ml determined by ELISA (QC Test). |
|
|
Cynomolgus c-MPL on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. |
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