Cynomolgus Cathepsin C/DPPI Protein (DPP-CM101)

Express System: HEK293
Product Tag: C-His
Purity: > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Activity: Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Arg-7-amido-4-methylcoumarin (GR-AMC). The specific activity is >8000 pmol/min/µg.
Amino Acid Range: Asp25-Leu463

Catalog #DPP-CM101

Price

$375⁰⁰

Size

Order by 4pm ET for delivery on:

Cynomolgus Cathepsin C/DPPI Protein (DPP-CM101) Summary

Product Description

Recombinant Cynomolgus Cathepsin C/DPPI Protein is expressed from HEK293 with His tag at the C-terminus.It contains Asp25-Leu463.

Product Background

Cathepsin C (CTSC) is a lysosomal cysteine protease constitutively expressed at high levels in the lung, kidney, liver, and spleen. It plays a key role in the activation of serine proteases in cytotoxic T cells, natural killer cells (granzymes A and B), mast cells (chymase and tryptase) and neutrophils (cathepsin G, neutrophil elastase, proteinase 3) underscoring its pivotal significance in immune and inflammatory defenses.

Cynomolgus Cathepsin C/DPPI Protein (DPP-CM101) Specifications/Details

Protein	Cathepsin C/DPPI
Synonyms	Cathepsin C; Cathepsin J; Dipeptidyl peptidase 1; CTSC; Dipeptidyl transferase
Accession	Q60HG6
Species	Cynomolgus
Biotinylated	no
Amino Acid Range	Asp25-Leu463
Molecular Weight	The protein has a predicted MW of 51.1 kDa. Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Activity	Measured by its ability to cleave the fluorogenic peptide substrate, Gly-Arg-7-amido-4-methylcoumarin (GR-AMC). The specific activity is >8000 pmol/min/µg.
Product Tag	C-His
Fluorophore	Unconjugated
Expression System	HEK293
Purity	> 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC
Endotoxin	Less than 0.1 EU per ug by the LAL method.

Shipping, Reconstitution, & Storage

Form	Liquid
Shipping	Shipped with dry ice.
Formulation	Supplied as 0.22 um filtered solution in 20mM MES, 150mM NaCl, 10% glycerol (pH 6.0).
Stability And Storage	Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Validation Images

	Cynomolgus Cathepsin C on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
	The purity of Cynomolgus Cathepsin C is greater than 95% as determined by SEC-HPLC.